The invention discloses a bipolar all-solid-state LTD square wave pulse generation circuit, which adopts an LTD circuit module, a pulse transformer and a load resistor RL, the LTD circuit module comprises a charging loop, a bipolar push-pull discharge loop, a load loop and a follow current loop, and the output end of the charging loop is connected with the input end of the bipolar push-pull discharge loop, the output end of the bipolar push-pull discharge loop is connected with a primary winding of the pulse transformer, the load loop, the follow current loop and the load resistor RL are all connected to a secondary winding of the pulse transformer, it is guaranteed that in a high-amplitude wide-pulse-width output mode, large overshoot cannot occur to the rear edge of a square wave, and bipolar high-voltage square wave pulses are output on a load. additional circuit is not needed for magnetic core reset, the pulse width of the output square wave can be continuously adjusted within the range from nanosecond to microsecond, the adjusting range of output parameters of the LTD circuit is greatly widened, and the parameter requirement of the tumor tissue irreversible electroporation ablation technology for a square wave pulse power supply can be met.