The invention relates to a method and device for integrally removing multiple pollutants in tail gas through plant ash seriflux. The method comprises the steps that plant ash seriflux is adopted for independently or jointly oxidize and remove SO2, NOx, Hg, H2S, HCl and HF in tail gas of a combustion or chemical device; tail gas containing SO2, NOx, Hg, H2S, HCl and HF from a boiler or kiln or chemical device is cooled and enters a rotary absorption reactor; soluble or acid gas SO2, NO2, Hg2+, H2S, HCl and HF can be directly washed and absorbed by a solution, and indissolvable gas NO and Hg0 can be absorbed by a solution after being pre-oxidized or oxidized by an additive into NO2, HNO2, HNO3 and Hg2+. According to the method, resource utilization can be achieved for solid waste produced by biomass burning, multiple pollutants can be integrally removed, the purpose of dealing with waste by waste is achieved, secondary pollution is avoided in the whole removal process, and the market development and application prospect is wide.