The invention discloses a production method of cobalt-chromium-alloy-based spherical niobium carbide powder. The production method comprises the steps of 1, drying cobalt-chromium alloy with the grainsize ranging from 45 microns to 150 microns and spherical niobium carbide with the grain size ranging from 45 microns to 150 microns for 2-4 hours at the temperature of 110-130 DEG C, wherein the spherical niobium carbide is prepared through a plasma method, and the content of niobium carbide is greater than 99%; 2, adding, by weight percentage, 50%-80% of the cobalt-chromium alloy and 20%-50% ofthe spherical niobium carbide into a three-dimensional powder mixer, wherein the rotating speed of the three-dimensional powder mixer is 15-20 r/min, and the time is 90-120 min; and 3, collecting thecobalt-chromium-alloy-based spherical niobium carbide powder. According to the production method of the cobalt-chromium-alloy-based spherical niobium carbide powder, operation is easy and convenientto conduct, the production cost is low, and industrialization is easy to achieve; the obtained cobalt-chromium-alloy-based spherical niobium carbide powder is good in flowability and suitable for massproduction; when the cobalt-chromium-alloy-based spherical niobium carbide powder is used as a coating, the problem that cracking is caused due to segregation is not likely to be generated; and the cobalt-chromium-alloy-based spherical niobium carbide powder is resistant to high temperature, corrosion and abrasion and can be applied to a plasma transferred arc surfacing process or a thermal spraying process, and the good commercial value is achieved.