41 results about "M-chloroaniline" patented technology

The invention discloses 2-chloro-4-fluorobenzoic acid and a preparation method thereof. In the method, m-chloroaniline is used as a raw material, and the protection of the amino group is realized through 2-(trimethylsilyl)ethoxymethyl chloride successively, and the Vilsmeier-Haack reaction is realized. Formylation, then oxidation to carboxylic acid, hydrogenation to reduce the nitro group, and then fluorination reaction to prepare 2-chloro-4-fluorobenzoic acid. The pesticide intermediate 2-chloro-4-fluorobenzoic acid provided by the present invention is simple to prepare, suitable for mass production, and uses cheap m-chloroaniline as a raw material, and uses a substance with low volatility and low toxicity as a reaction during the preparation process. Medium, reasonably control the type and amount of catalyst and oxidant, so that the yield of the product can reach more than 85%.

The invention provides N,N-diacetoxyethyl-m-chloroaniline series azo dyes. The general formula of the dyes is shown below, wherein R1 represents H, NO2, Cl, Br or COMMUNICATION and R2 represents H, NO2, Cl, Br or CN. The preparation method of the dyes comprises the following steps: using paranitroaniline or a derivative of paranitroaniline as diazo component to perform diazotization, and then reacting with N,N-diacetoxyethyl-m-chloroaniline to obtain orange or orange-red disperse dye which can have a single structure and be used to directly prepare dyes with mixed structures. The type of dyes are used to dye polyester fiber in dye liquor which is from weakly acidic to weakly alkaline; and the dyes have bright colors, good levelling property and redyeing property, high lifting force and excellent color fastness properties.

The invention discloses a method for preparing 7-chloroquinaldine by use of a phase-transfer catalytic reaction. M-chloroaniline and crotonaldehyde are used as raw materials, lauryl sodium sulfate (serving as a surface active agent) and phosphomolybdic acid (serving as a oxidizing agent) are added in a water and 2-butanol reaction system for reaction to obtain the 7-chloroquinaldine with high yield. Compared with the prior art, the method has the remarkable advantages that (1) the lauryl sodium sulfate is added to enhance emulsibility of reaction liquid, the generation of byproducts (5-isomer) is inhibited, and the reaction efficiency is greatly improved; (2) the phosphomolybdic acid is also added, as the oxidizing agent has common gender of acid, the traditional acid solvent is avoided, and the property of the oxidizing agent can be realized; (3) the reaction can be performed in water, the aftertreatment is simple, and the reaction yield (up to 89%) is greatly improved.

The invention relates to a preparation method of fine sulfanilamide and particularly relates to a preparation method of high-purity fine sulfanilamide. The preparation method sequentially comprises the following steps of: proportioning m-chloroaniline, chlorosulfonic acid and phosphorus trichloride, then, mixing chlorosulfonic acid, m-chloroaniline and phosphorus trichloride at the temperature of 30-45 DEG C, heating to 105-120 DEG C and carrying out heat preservation for 2-4hours; standing and cooling to obtain a chlorosulfonated substance; introducing ammonia gas to an amination reaction device for the first time, adding the obtained chlorosulfonated substance, then, introducing ammonia gas to the amination reaction device for the second time, carrying out amination reaction at the temperature of 40-45 DEG C and the pressure of 0.1-0.2MPa, and carrying out heat preservation for 1-3hours to obtain an amide; and carrying out dissolution, decoloration, crystallization and purification on the obtained amide: adding a sodium hydroxide solution to adjust the pH value to 10-11, then, adding active carbon, heating to 80-95 DEG C, carrying out heat preservation for 0.3-0.8h, filter pressing while the solution is hot, adding hydrochloric acid into the obtained filtrate to adjusting the pH to 2-4, separating out white crystal substances, and then, cooling, washing, centrifuging and drying to obtain a finished product of the fine sulfanilamide. The preparation method is few in reaction by-product and high in product purity.

The invention discloses a preparation method of fenbendazole and provides a brand-new synthesis route of the fenbendazole. The fenbendazole is prepared from m-dichlorobenzene as a starting material through the steps of nitrification, condensation, amination, reduction and cyclization. The preparation method is characterized in that the starting material m-chloroaniline in the existing industrial route is changed to the cheap m-dichlorobenzene; the existing reduction technology with sodium sulfide dihydrate is changed to the clean and high-efficiency reduction technology; and the new synthesis technology is concise and simple, high in efficiency, slight in pollution, high in quality, and suitable to industrial production.

A heterocycle azo yellow disperse dye is disclosed. The molecular structure of the disperse dye is shown as (I). A preparing method of the disperse dye is also disclosed. The method includes a step of adding water and m-chloroaniline or m-chloroaniline hydrochloride into a reaction pot, adding hydrochloric acid having a concentration of 30% under stirring, adding ice cubes, cooling to 0-5 DEG C, and adding a sodium nitrite solution having a concentration of 30% to obtain a diazonium salt solution; a step of adding water and sodium carbonate into a coupling pot, adding N-butyl pyridine under stirring, stirring, adding hydrochloric acid having a concentration of 8%, adding ice cubes, and cooling to 5-10 DEG C to obtain a coupling component; a step of adding the prepared diazonium salt solution into the coupling component, adjusting the pH value of a reaction product to 0.5-1.5, reacting for 4-5 h, heating to 50 DEG C, filtering, and rinsing until the product is neutral to obtain the disperse dye. The disperse dye is wide in dye solution pH range, almost same in colored light, and good in light fastness and soaping fastness. The formula (I) is shown in the specification.

The present invention provides a preparation method of medicine intermediate 7-chlorine quinaldine. M-chloroaniline salt of inorganic acid and crotonaldehyde have a closed loop reaction in mixed solvent of alcohol and arene to prepare the salt of 7-chlorine quinaldine; alkaline is added for neutralization; and the 7-chlorine quinaldine can be prepared. The present invention has the advantages that the production of a large quantity of isomers is inhibited, the operation is simple, the production period is obviously shortened, no large amount of acid, alkaline or expensive solvent is used in the post-processing, and the product is more conducive to the environmental protection; a large amount of energy is saved; simultaneously, the reaction conditions are simplified, the reaction process is safer and more reliable, the quality and yield rate of the product are ensured, and the present invention is more suitable for industrial production.

The invention discloses a method for producing chlorpropham, which comprises the following steps of: performing bubbling degassing treatment on isopropyl chlorocarbonate at the temperature of between 5 and 40DEG C under negative pressure condition; controlling content of isomerides of a raw material of m-chloroaniline to be within 0.2 percent, adding the m-chloroaniline into caustic soda liquid, and adding the treated isopropyl chlorocarbonate for reaction; regulating the PH value of reaction liquid to be 6-8 by using dilute acid, adding deionized water for washing and demixing, and obtaininga lower oil layer, namely a crude product of chlorpropham; and dehydrating the crude product to obtain the qualified product. By pretreating the raw material and acidifying synthetic liquid, the product quality is improved and production energy consumption is reduced.

The invention relates to a method for preparing m-chloroaniline by using meta-position oil, which belongs to the technical field of preparing m-chloroaniline, and specifically includes the steps of batching reaction, water washing, drying, three-stage vacuum distillation, crystallization, reduction, redistillation and the like. The present invention uses waste meta-oil produced by p- and o-nitrogen and industrial waste liquid sodium hydrosulfide as raw materials, utilizes methoxylation, crystallization and reduction to prepare m-chloroaniline, and generates by-products o-aminoanisole and p- Anisole, thereby realizing low cost, high output, compared with existing production technology, has obvious cost advantage, has higher economic benefit.

The invention relates to a liquid fluorescent whitening agent and a preparation method thereof and mainly aims at solving the technical problems that the whitening effect is not obvious and the stability is poor in an existing fluorescent whitening agent and a preparation method thereof. According to the technical scheme, the fluorescent whitening agent is mainly composed of V, VI, VII and VIII. The preparation method of the liquid fluorescent whitening agent comprises the following steps: with cyanuric chloride, 4,4'-diamino diphenylethene-2,2'-disulfonic acid, phenylamine, m-chloroaniline, acrylic acid and serine in ratio by amount of substance of 1.0:(0.45-0.55):(0.45-0.55):(0.45-0.55):1.0:(0.95-1.05) as raw materials, firstly dissolving acrylic acid and serine in water to generate a mixture of I and II, then mixing 4,4'-diamino diphenylethene-2,2'-disulfonic acid with an NaOH solution to prepare a sodium 4,4'-diamino diphenylethene-2,2'-disulfonate solution, adding the sodium 4,4'-diamino diphenylethene-2,2'-disulfonate solution, an emulsifier and cyanuric chloride into ice water, and carrying out reaction to generate a product III; adding phenylamine and m-chloroaniline into III to generate IV; and finally adding the mixture of I and II into IV to obtain a whitening agent crude product, and then carrying out suction filtration, desalination and concentration to obtain the liquid fluorescent whitening agent product.

The invention relates to a stilbene triazine fluorescent whitening agent special for a detergent and a preparation method thereof, and aims at solving the technical problems that an existing fluorescent whitening agent for the detergent is not obvious in whitening effect, complex in preparation method and high in cost. According to the technical scheme, the stilbene triazine fluorescent whiteningagent special for the detergent is prepared from a component I, a component II and a component III according to the mass ratio of 6:3:1, wherein the component I is 4, 4'-bis[(4-anilino-6-hydroxydiethylamino-1, 3, 5-triazine-2-yl)amino]stilbene-2, 2'-disodium disulfonate, the component II is 4, 4'-bis[(4-anilino-4'-m-chloroanilino-6-hydroxydiethylamino-1, 3, 5-triazine-2-yl)amino]stilbene-2, and the component III is 4, 4'-bis[(4-m-chloroanilino-6-hydroxydiethylamino-1, 3, 5-triazine-2-yl)amino]stilbene-2. The fluorescent whitening agent prepared by the invention is low in cost and good in whitening effect, and can completely meet market requirements when being used alone.

The invention discloses a novel synthetic method of a ziprasidone intermediate. The synthetic method comprises following steps: m-chloronitrobenzene is taken as an initial raw material, and is subjected to nitroreduction so as to obtain m-chloroaniline; m-chloroaniline is subjected to aminoacylation so as to obtain 3-chloroacetyl amino-chloro-benzene; and finally 3-chloroacetyl amino-chloro-benzene is subjected to Friedel-Crafts alkylation, and 6-chloro-2-indolone is obtained after cyclization. The raw materials of the synthetic method are cheap and easily available, synthetic route is short, yield is high, operation is convenient, cost is low, and the synthetic method is suitable for industrialized application.