35 results about "P-Aminosalicylic Acid" patented technology

The present invention uses water or low-grade alcohol with a certain concentration as solvent, dissolves the isoniazid in the above-mentioned solvent, then adds the p-aminosalicylic acid, and adopts the processes of heating, stirring, cooling and separation so as to obtain the invented product pasiniazide.

The invention relates to the field of pharmaceutical chemistry, in particular to a novel crystal form of p-aminosalicylic acid and a preparation method thereof. A crystal in the novel crystal form is subjected to X-ray powder diffraction, diffraction peak positions 2theta are used as spectrogram characteristic parameters, and 2theta are 7.36+ / -0.2, 14.61+ / -0.2, 17.01+ / -0.2, 21.91+ / -0.2 and 29.28+ / -0.2 sequentially. The preparation of the crystal comprises steps of mixing p-aminosalicylic acid and an organic solvent, then utilizing a temperature differential method for crystallization, carrying out solid-liquid separation, drying solid, and obtaining the crystal in the novel crystal form. The invention further relates to preparations or compositions containing the novel crystal form, and applications of the novel crystal form to preparations of drugs for treating tuberculosis. The novel crystal form of p-aminosalicylic acid is good in stability, and not only has storage and transportation advantages, but also greatly facilitates industrial production.

The present invention relates to a licorzinc solution composition, including licorzinc, solvent and cosolvent, the zinc content in the licorzinc is 4.0-20.0%, the solvent is water or oil, and the cosolvent is one of the following substances: citric acid and its potassium salt, sodium salt and iron salt, tartaric acid and its potassium salt, sodium salt and iron salt; glucose and its potassium salt, sodium salt and iron salt and P-aminosalicylic acid and its potassium salt, sodium salt and iron salt, and the ratio of licorzinc and cosolvent is 1:0.4-1:1.5, and the concentration of said licorzinc solution is 0.01%-10%. Said invention can be made into several dosage forms, and can raise its biological utilization rate.

The invention relates to a preparation method of isoniazid para-aminosalicylate. The preparation method of isoniazid para-aminosalicylate comprises the following steps: (1) respectively weighting water and an organic solvent, mixing, adding para-aminosalicylic acid and isoniazid to a solvent of the water and the organic solvent, heating and stirring; (2) cooling and growing grains, and filtering to obtain isoniazid para-aminosalicylate, wherein the organic solvent is an organic ester with the carbon number of less than or equal to 6. By using the preparation method, the preparation of isoniazid para-aminosalicylate is realized at low cost and high efficiency in a water and ester two-phase solvent system under a simple, convenient and feasible technological condition. The content of isoniazid para-aminosalicylate prepared by the method is higher than 99%. Isoniazid para-aminosalicylate has good appearance crystal form, standard color and luster and good stability. The preparation method has the advantages of few reaction operating units, simple technological process, short time consumption, low production cost, environmental friendliness, simple operation and easiness for control on the implementation process and is suitable for the industrial production of isoniazid para-aminosalicylate.

A method for industrial production of formula I, using p-aminosalicylic acid, potassium salt and carbon dioxide as raw materials, the reaction is carried out in molten potassium formate, so that multi-substituted benzene rings can reintroduce carboxyl groups under mild conditions. Compared with the prior art, the present invention reacts under normal pressure, has safe production operation, does not need expensive high-pressure reactors, and saves costs; and while reducing the reaction pressure, it not only does not need to increase the time required for the reaction, but instead Significantly reduced reaction time

The invention discloses a fluoroquinolone derivative of p-aminosalicylic acid, an intermediate, a preparation method and an application thereof, and belongs to the technical field of drug synthesis; the structural formula of the fluoroquinolone derivative of p-aminosalicylic acid is as follows; in vitro antibacterial activity assay The results showed that the antibacterial activity of the target compounds against bacteria was generally good; most of the compounds had good antibacterial activities against Pichia pastoris, and some compounds were even more active than the positive control drugs; The inhibitory activity of mycobacteria is stronger than that of most positive control drugs; some target compounds have inhibitory activity against citrus pathogens; the fluoroquinolone derivatives and intermediates of p-aminosalicylic acid of the present invention have antibacterial, antifungal, antituberculous and antibacterial properties. The field of citrus pathogens has potential application prospects.