The invention relates to a production method for an extrusion injection bone for a pet. According to the production method, cowhide, pigskin, fish skin crushed particles, meat and bone meal, muddy flesh, glycerol and natural perfume are served as principal raw materials; the cowhide, the pigskin and the fish skin particles are soaked in water; or fresh skin of cattle, pigs and fish are ground into skin particles with the size of 10 to 12 meshes through a meat grinder; the skin particles are ground into skin mud through a bone mud machine; the skin mud is stirred into skin glue in a kneading machine with a high temperature and is continued to be stirred after the meat and bone meal, animal protein powder and the glycerol are added into the kneading machine; materials are took out from the kneading machine to perform air drying and cut into small blocks; the small blocks are extruded and granulated into particles through a granulating machine; and injection molding is performed on the particles through an injection molding machine after being dried. Compared with the common pet teeth cleaning bone, the edible injection bone for the pet has the advantages of being rich in nutrition, having special aroma of the skin, the meat and the bone, taking functions of food tempting, dental caring and oral cavity cleaning and being high in tenacity, easy to digest, free of starch adding, high in compactness, low in moisture and capable of being performed as snacks for the pet to clean the teeth and chew.