The invention discloses a planting method of high-yield momordica charantia L. The method comprises the following steps of 1, seed fermentation, wherein bitter gourd seeds and momordica charantia L seeds are sterilized and soaked at first, and then the seeds and organic matter are mixed for low-temperature fermentation; 2, seedling raising, wherein organic fertilizer and soil are mixed and laid ona seeding raising bed of a greenhouse, and the fermented bitter gourd seeds and the fermented momordica charantia L seeds are mixed and sowed from mid-March to the end of March; 3, grafting, whereinthe upper portions of momordica charantia L seedlings are cut as scions, bitter gourd seedlings are selected as rootstocks, the scions and the rootstocks are combined for wrapping and placed in the greenhouse till cuts heal; 4, soil preparation, wherein after soil ploughing, a chlorothalonil solution is sprayed, lime powder is applied, then the organic fertilizer is applied, and bedding managementand plastic film covering are conducted for standing after ploughing; 5, transplanting, wherein grafted seedlings are transplanted, a planting frame with a roof is set up, and sunshade nets are covered; 6, management in a later period, wherein a chlorothalonil solution is used for spraying at fixed time, lateral buds are pruned two months after transplanting, and ternary compound fertilizer is used for topdressing half a month before flowering.