The present invention discloses a BiSbTeSe-based thermoelectric material, whose general formula is BimSbnTexSeyMz; wherein, m=0.4-0.6, n=1.4-1.6, x=2.7-2.9, y=0.075-0.3, z=0.02-0.15, M is one or more elements of S, Si, P, Ge, Sn, Ce, Li, I, Br, Al, Cu, Ag, Yb, Tm, La, Gd and Dy. The BiSbTeSe-based thermoelectric material is prepared through powder mixing, alloy smelting and other steps. The BiSbTeSe-based thermoelectric material in the present invention has the advantages of low thermal conductivity and good thermoelectric properties, which expands the application area of thermoelectric material.