The invention provides an acne removing composition prepared from medicine-food homologous medicinal materials fully. The acne removing composition is used for radically treating acne through detoxifying, eliminating dampness and regulating incretion in a manner of starting from the inside. The inventor carries out treatment in a manner of referring to modern pharmacological researches, abiding by the theory of the traditional Chinese medicine and holding the principle that the oral administration of traditional Chinese medicine preparations is taken as a basis and the external wipe of traditional Chinese medicine preparations is taken as a complement. The acne removing composition is prepared from raw materials, namely gordon euryale seed, medlar, finger citron, emblic leafflower fruit, purple perilla, kudzu root, hawthorn fruit, sterculia lychnophora hance, cassia seed, coix seed, peach kernel, mulberries, cinnamon, longan, honeysuckle flower, peppermint, chicory, lotus seed, gardenia and wild jujube seed, has the effects of heat clearing, detoxifying, incretion regulating and acne removing and is used for easing or healing stubborn acne. According to the composition provided by the invention, a formula of the composition fully consists of medicine-food homologous drugs, and the raw materials are wide in source, cheap in price and low in toxic and side effect, so that the composition is suitable for industrialized production and popularization and application.