The invention discloses a blockage preventive device of a tobacco slicing machine. The blockage preventive device comprises a cutter, a worktable, a downstream machine, a barrier, a guide plate, a reset mechanism and an alarm mechanism. The cutter is positioned above the worktable, the downstream machine is positioned below the barrier, and the barrier is fixedly arranged on the lower side of theworktable; the guide plate is positioned on the right side of the barrier, only tobacco bales with the sizes smaller than or equal to approval standards are allowed to pass gaps between the guide plate and the barrier, the alarm mechanism is elastically connected with the guide plate by the reset mechanism, the reset mechanism can be driven by the guide plate to move rightwards to trigger the alarm mechanism if the guide plate is squeezed when tobacco bales with the sizes larger than the approval standards fall down, the tobacco bales with the sizes larger than the approval standards can fallon the downstream machine, and the guide plate can be reset by the reset mechanism. The blockage preventive device has the advantages that the blockage frequencies of the tobacco slicing machine can be effectively reduced by the blockage preventive device, accordingly, the production continuity can be improved, and the production efficiency of enterprises can be improved; alarm effects can be realized for blockage, accordingly, operators can be reminded of timely handling blockage, and material deficiency of production lines can be prevented.