The invention discloses a vacuum laminating fixture and method for 3D curved surface glass and an explosion-proof film. The vacuum laminating fixture comprises a machine frame base and a 3D curved surface glass laminating device arranged above the machine frame base, an outer cover is arranged on the surface of the 3D curved surface glass laminating device in a sleeving mode, the outer cover is fixedly connected with the machine frame base, the 3D curved surface glass laminating device comprises a supporting cross beam, an overturning upper box body, a movable lower box body, a curved surfaceglass sheet conveying mechanism, a curved surface glass sheet grabbing mechanism, a curved surface glass sheet positioning mechanism, a silica gel soft mold bearing mechanism, a back adhesive anti-explosion film sheet positioning mechanism, a back adhesive anti-explosion film sheet laminating lifting mechanism and a back adhesive anti-explosion film sheet conveying mechanism. The vacuum laminatingfixture and method for the 3D curved surface glass and the explosion-proof film has the advantages that the structure is simple, the use is convenient, pasting of a back adhesive of the curved surface glass product can be quickly realized, the error is within +/-0.05 mm, no bubbles and wrinkles exist between the back adhesive explosion-proof film sheet and the attaching surface of the curved surface glass sheet, so that the quality of the curved surface glass product is improved, meanwhile, the yield of the product is improved, and the production cost is greatly reduced.