The invention relates to the technical field of biomedical nano materials, and discloses a
targeted radiotherapy sensitizer, a bionic nano
delivery system and a preparation method and application of the
targeted radiotherapy sensitizer and the bionic nano
delivery system. The preparation method of the
targeted radiotherapy sensitizer comprises the following steps: dissolving
triphenylphosphine and a polypeptide condensing agent in
anhydrous DMF (
Dimethyl Formamide), and uniformly stirring; then adding an SH-PEG2000-NH2 solution, and carrying out a reaction, so as to obtain SH-PEG2000-TPP (
Triphenyl Phosphate); heating and refluxing the
chloroauric acid solution, adding a
sodium citrate solution, and reacting to obtain an AuNPs dispersion liquid; the preparation method comprises the following steps: mixing an AuNPs dispersion liquid, SH-PEG2000-NH2 and SH-PEG2000-TPP, and carrying out a reaction, so as to obtain AuNP-PEG2000-TPP nanoparticles, namely the targeted radiotherapy sensitizer. After entering tumor mitochondria, the targeted radiotherapy sensitizer disclosed by the invention can effectively absorb
ray energy through X-
ray irradiation, convert the
ray energy into
heat energy and
electron excitation energy, generate
reactive oxygen species (ROS), further activate inflammatory small bodies and
caspase-1, then generate N-terminal GSDMD
protein fragments, start a
pyroptosis process and play a relatively strong radiotherapy
sensitization role; proinflammatory cytokines such as IL-1beta and IL-18 are released in the
pyroptosis process, and local immune response is further expanded.