52results about How to "Applicable to a wide range of substrates" patented technology

The invention provides a preparation method of a multilayer antireflection coating, comprising the following steps: (1) dispersing one or more of SiO2 particles, Al2O3 nanoparticles, and TiO2 nanoparticles in a solvent by a mechanical dispersion method to form a first nano dispersion liquid; (2) dispersing one or more of SiO2 particles, Al2O3 nanoparticles, and TiO2 nanoparticles in a solvent by a mechanical dispersion method to form a second nano dispersion liquid which is different from the first nano dispersion liquid, or dispersing one or more of SiO2 particles, Al2O3 nanoparticles, and TiO2 nanoparticles in a solvent by a sol-gel method to prepare a third nano dispersion liquid; and (3) preparing a coating: coating the first nano dispersion liquid prepared by the step (1) and the second or the third nano dispersion liquid prepared by the step (2) on a substrate and solidifying to form a coating. The method disclosed herein has the advantages of low reflectivity and high transmitance in full-waveband of visible lights, simple production process, low cost and wide suitable substrates, and the like.

The invention discloses a chiral nitrogen oxygen bridge ring skeleton and spiro oxindole compound and a synthesis method of the compound. The method specifically comprises the following steps: takinga 3-pyrrolyl oxindole and beta,gamma-unsaturated alpha-keto ester derived from salicylaldehyde as a reactant, and in the presence of a chiral thiourea compound and bis(trifluoromethanesulfonyl)imide,performing an asymmetric tandem cyclization reaction in a methyl tert-butyl ether and toluene solvent to obtain a product. The method disclosed by the invention has simple and easily available raw materials, mild reaction conditions, simple and convenient post-treatment, wide application range, good yield, and high enantioselectivity and non-enantioselectivity; and therefore, the synthesized product has a potential medicinal value.

The invention discloses a chiral 3, 4-dihydrogen-2(1H)-quinolinone compound and a preparation method and belongs to the technical field of compound preparation. The preparation method includes: takingvinyl benzoxazinone and oxazolone as a synthetic building block, adding a metal palladium catalyst, phosphorus-ligand and acid-alkali additive, and allowing reaction at room temperature to obtain thecompound. The preparation method is mild in reaction condition, high in reaction speed, simple in aftertreatment and wide in substrate range. A method for selective synthesis of diastereomer of 3, 4-dihydrogen-2(1H)-quinolinone having extensive physiological and pharmacological activities like resistance to tumor, high blood pressure and tuberculosis and pain stopping is brand-new and efficient.

The invention discloses a synthesis method of a spiro hydroxyindolocyclopentane beta-exo fat compound. The synthesis method comprises the following step: by taking phenyl unsaturated aldehyde and unsaturated ketoacid ester as reactants and by taking n-heterocyclic carbene as a catalyst, performing reaction, thus obtaining the spiro hydroxyindolocyclopentane beta-exo fat compound. According to the method disclosed by the invention, the raw materials are simple and readily available; the reaction conditions are mild; post-treatment is simple and convenient; the synthesis method is wide in application substrate range, high in yield and high in diastereoselectivity and enantioselectivity; therefore, a synthesized product can be used for synthesizing an intermediate of a medicine and a pesticide.

The present invention discloses a spiro oxindole imidazolinyl oxazepine compound and a synthesis method thereof, wherein particularly diazo oxindole and dibenzoxazepine are adopted as reactants, and synthesis is performed in a solvent under catalysis of iron trifluomethanesulfonate (II) or a p-toluenesulfonic acid monohydrate to obtain the product. According to the present invention, the method has characteristics of simple and easily-available raw materials, mild reaction conditions, simple and convenient post-treatment, wide substrate application range, high yield and high diastereoselectivity; and the synthesized product can be used for synthesizing the intermediate of drugs and insecticides.

The invention discloses a synthesis method of a chiral 3,4-dihydrocoumarin derivative compound. The method specifically comprises steps as follows: 2-hydroxychalcone and azlactone are taken as reactants, and a product is synthesized in a solvent under the catalysis of multifunctional chiral quinine thiourea. According to the method, raw materials are simple and easy to obtain, reaction conditions are mild, post-treatment is simple and convenient, the applicable substrate range is wide, the yield is high, and the enantioselectivity is high; the synthesized product can be used for synthesizing intermediates of drugs and insecticides.

The invention discloses a synthesis method of a chiral spiro tetrahydrofuran pyrazolone compound, which specifically comprises the following steps: by taking vinyl cyclic carbonate and alpha, beta-unsaturated pyrazolone as reactants, Pd (PPh3) 4 as a metal and a chiral phosphorus ligand as a chiral ligand, reacting in an organic solvent to obtain the chiral spiro tetrahydrofuran pyrazolone compound. The method disclosed by the invention has the advantages of simple and easily available raw materials, mild reaction conditions, simple and convenient post-treatment, wide applicable substrate range, high yield and high enantioselectivity; the synthesized product can be used for synthesizing an intermediate of a medicine.

The invention discloses a method for preparing olefin by deoxidizing and dehydrating a polyhydroxy compound by using an alcohol as a reducing agent. The method is characterized in that raw materials containing a polyhydroxy compound and a catalyst react in the presence of an alcohol reducing agent to obtain olefin. According to the method for deoxidizing and dehydrating a polyhydroxy compound by using primary alcohol, secondary alcohol, tertiary alcohol, benzyl alcohol and other alcohols are used as reducing agents, the alcohol reducing agent is cheap and environmentally-friendly, and has universality to the deoxidation dehydration reaction of the polyhydroxy compound.

Belonging to the technical field of compound preparation, the invention relates to a chiral barbital spiro tetrahydroquinoline compound and a preparation method thereof. The method specifically includes: taking a vinyl benzoxazinone compound and a barbital olefin compound as the reactants, also adding a metal palladium catalyst and a phosphorus-containing chiral ligand, and carrying out reaction at room temperature to obtain the product. The preparation method has the advantages of mild reaction conditions, fast reaction speed, simple post-treatment, and wide range of applicable substrates, and also most of the synthesized target compounds have high yield, excellent enantioselectivity and non-enantioselectivity. The method is a brand new method for efficient synthesis of chiral barbital spiro tetrahydroquinoline compound with potential medicinal value.

The invention discloses imidazolyl ionic liquid as formula I and a synthesizing method thereof. When the imidazolyl ionic liquid is applicable to Knoevenagel reactions, the imidazolyl ionic liquid has the advantages that imidazolyl ionic liquid is wide in applicable substrate range, short in reaction time, mild in reaction actions, and reusable.

The invention discloses a synthesis method of a chiral phosphorus-contained pyrazolone compound. The synthesis method concretely comprises the step: with pyrazolidinone imine and diaryl phosphorus oxide or dimethyl phosphite as a reactant, synthesizing the chiral phosphorus-contained pyrazolone compound in a solvent under the analysis of multifunctional chiral squaric acid amide. The method disclosed by the invention is simple and easy to obtain raw material, mild in reaction condition, simple and convenient for after-treatment, wide in applicable substrate range, high in yield and high in enantioselectivity; in addition, the chiral phosphorus-contained pyrazolone compound synthesized by using the method can be used for synthesizing an intermediate of a drug and an insecticide.

The invention discloses a 2-phosphonyl-3-fluoro vinyl indole compound which is complex and diverse in structure, contains phosphonyl, an indole ring and fluoro vinyl, can be subjected to further structural modification and serves as an important intermediate for organic synthesis. After the phosphonyl is reduced into trivalent phosphine, the trivalent phosphine can also be used as an important phosphine ligand to participate in organic synthesis reaction catalyzed by transition metal and the like. According to the synthetic method of the 2-phosphonyl-3-fluoro vinyl indole compound, in the air atmosphere, a difluoromethyl indole methanol compound and a disubstituted phosphine oxide compound serve as raw materials and react in a solvent, and the method is simple, free of any catalyst, environmentally friendly, mild in reaction condition, high in yield and wide in reaction substrate range. The 2-phosphonyl-3-fluoro vinyl indole compound disclosed by the invention can be used as a ligand and an organic synthesis intermediate, and has a wide application prospect.

Five-membered and six-membered carbon ring chiral oxindole spiro skeletons widely exist in active natural products and drug molecules, and development of a high-efficiency synthesis method of the chiral spiro compounds and analogues thereof will promote development of new drugs. Indolone which is cheap and easy to obtain and an amphiphilic electroalkylating reagent are adopted as raw materials, novel and efficient [4 + 1] and [5 + 1] cyclization reactions are developed under the condition of asymmetric phase transfer catalysis, and therefore general synthesis of chiral oxoindole spiro rings containing five-membered and six-membered carbon rings can be rapidly constructed in one step, and the chiral oxoindole spiro rings containing five-membered and six-membered carbon rings can be obtained. And the one-step synthesis of the key chiral spiro intermediate of the medicine ubrogepant is realized. The method is mild in reaction condition and simple in process, the target compound can be obtained without water-free and oxygen-free operation, the requirement for production equipment is low, the substrate application range is wide, and the method has extremely high industrial application value.

The invention discloses a solid self-lubricating coating and a preparation method thereof.The coating is formed by compounding a hard diamond-like phase serving as an intrinsic supporting layer and a soft graphitization phase serving as a surface lubricating layer, the hard diamond-like phase is formed by mixing sp2 and sp3 hybrid carbon structures, and the atomic percentage content of sp3 is 25-70%; the soft graphitized phase is mainly composed of an sp2 hybrid carbon structure, the atomic percentage content of sp2 is 90% or above, and the content of a six-membered ring structure is 60% or above; the composite lubricating coating has the advantages of high hardness, high bearing capacity, low abrasion, super-lubricity and friction coefficient lt; 0.01, the solid self-lubricating coating material can provide wear-resistant lubricating protection for a matrix or a workpiece in various environments such as high load and high speed, the preparation method is simple, the operability is high, industrial production is easy, and the solid self-lubricating coating material is excellent in comprehensive performance, long in service life and high in reliability.

The invention discloses an ultralow-friction solid-liquid composite lubricating coating and a preparation method thereof, and belongs to the technical field of material surface coating. The diamond-like coating is arranged on two or more base bodies with the mutual friction working condition, the diamond-like coating is arranged on the friction face where the base bodies rub with each other, and a lubricating oil layer serving as an intermediate liquid phase is arranged between the diamond-like coatings of the two or more base bodies with the mutual friction working condition. Only the surface of the diamond-like carbon coating is hydrogenated, and the percentage content of H element atoms contained in the hydrogenated surface is 3%-38%. The diamond-like solid phase has high hardness, good toughness and good bearing performance, and the formed solid-liquid composite lubricating coating has extremely low friction coefficient (0-0.01) and wear rate, so that the diamond-like solid phase composite lubricating coating is a composite lubricating coating material with excellent comprehensive performance, long service life and high reliability.

The invention discloses a synthesis method of a 2, 3-diamino indole compound, which belongs to the technical field of chemical synthesis, and comprises the following operation steps: adding o-ethynylaniline, arylamine, lithium perchlorate, tetrabutylammonium iodide and tetramethylpiperidine oxide into a three-necked bottle, finally adding a solvent, under the condition of electrification, taking a platinum electrode as an anode, and reacting for 2-4 hours to obtain the 2, 3-diamino indole compound. The preparation method comprises the following steps: by taking an organic solvent as a cathode and a carbon electrode as a cathode, stirring and reacting for 8-12 hours under a constant-current condition, after the reaction is finished, extracting reaction liquid, carrying out rotary evaporation on the extracted reaction liquid, and carrying out silica gel column chromatography separation to obtain a target product, according to the method, metal catalysis is not needed, the reaction can be carried out at normal temperature, mild reaction can be carried out in a solvent system of water and acetonitrile, the method is particularly suitable for synthesis of some drugs, the problems of metal residues and the like are fundamentally solved, and high economic applicability is achieved; the problems that expensive transition metal is basically used and higher reaction temperature is needed in the existing method are solved.