52results about How to "Applicable to a wide range of substrates" patented technology

The invention provides a preparation method of a multilayer antireflection coating, comprising the following steps: (1) dispersing one or more of SiO2 particles, Al2O3 nanoparticles, and TiO2 nanoparticles in a solvent by a mechanical dispersion method to form a first nano dispersion liquid; (2) dispersing one or more of SiO2 particles, Al2O3 nanoparticles, and TiO2 nanoparticles in a solvent by a mechanical dispersion method to form a second nano dispersion liquid which is different from the first nano dispersion liquid, or dispersing one or more of SiO2 particles, Al2O3 nanoparticles, and TiO2 nanoparticles in a solvent by a sol-gel method to prepare a third nano dispersion liquid; and (3) preparing a coating: coating the first nano dispersion liquid prepared by the step (1) and the second or the third nano dispersion liquid prepared by the step (2) on a substrate and solidifying to form a coating. The method disclosed herein has the advantages of low reflectivity and high transmitance in full-waveband of visible lights, simple production process, low cost and wide suitable substrates, and the like.

The invention discloses a chiral nitrogen oxygen bridge ring skeleton and spiro oxindole compound and a synthesis method of the compound. The method specifically comprises the following steps: takinga 3-pyrrolyl oxindole and beta,gamma-unsaturated alpha-keto ester derived from salicylaldehyde as a reactant, and in the presence of a chiral thiourea compound and bis(trifluoromethanesulfonyl)imide,performing an asymmetric tandem cyclization reaction in a methyl tert-butyl ether and toluene solvent to obtain a product. The method disclosed by the invention has simple and easily available raw materials, mild reaction conditions, simple and convenient post-treatment, wide application range, good yield, and high enantioselectivity and non-enantioselectivity; and therefore, the synthesized product has a potential medicinal value.

The invention discloses a chiral 3, 4-dihydrogen-2(1H)-quinolinone compound and a preparation method and belongs to the technical field of compound preparation. The preparation method includes: takingvinyl benzoxazinone and oxazolone as a synthetic building block, adding a metal palladium catalyst, phosphorus-ligand and acid-alkali additive, and allowing reaction at room temperature to obtain thecompound. The preparation method is mild in reaction condition, high in reaction speed, simple in aftertreatment and wide in substrate range. A method for selective synthesis of diastereomer of 3, 4-dihydrogen-2(1H)-quinolinone having extensive physiological and pharmacological activities like resistance to tumor, high blood pressure and tuberculosis and pain stopping is brand-new and efficient.

The invention discloses a synthesis method of a spiro hydroxyindolocyclopentane beta-exo fat compound. The synthesis method comprises the following step: by taking phenyl unsaturated aldehyde and unsaturated ketoacid ester as reactants and by taking n-heterocyclic carbene as a catalyst, performing reaction, thus obtaining the spiro hydroxyindolocyclopentane beta-exo fat compound. According to the method disclosed by the invention, the raw materials are simple and readily available; the reaction conditions are mild; post-treatment is simple and convenient; the synthesis method is wide in application substrate range, high in yield and high in diastereoselectivity and enantioselectivity; therefore, a synthesized product can be used for synthesizing an intermediate of a medicine and a pesticide.

The present invention discloses a spiro oxindole imidazolinyl oxazepine compound and a synthesis method thereof, wherein particularly diazo oxindole and dibenzoxazepine are adopted as reactants, and synthesis is performed in a solvent under catalysis of iron trifluomethanesulfonate (II) or a p-toluenesulfonic acid monohydrate to obtain the product. According to the present invention, the method has characteristics of simple and easily-available raw materials, mild reaction conditions, simple and convenient post-treatment, wide substrate application range, high yield and high diastereoselectivity; and the synthesized product can be used for synthesizing the intermediate of drugs and insecticides.

The invention discloses a synthesis method of a chiral 3,4-dihydrocoumarin derivative compound. The method specifically comprises steps as follows: 2-hydroxychalcone and azlactone are taken as reactants, and a product is synthesized in a solvent under the catalysis of multifunctional chiral quinine thiourea. According to the method, raw materials are simple and easy to obtain, reaction conditions are mild, post-treatment is simple and convenient, the applicable substrate range is wide, the yield is high, and the enantioselectivity is high; the synthesized product can be used for synthesizing intermediates of drugs and insecticides.

The invention discloses a N-(3,4-dihydroxyl phenyl)ethyl-methacrylamide copolymer and a preparation method therefor. By taking dopamine and a fluorine-containing compound as raw materials, the dopamine is modified by using the fluorine-containing compound by virtue of a copolymerization method so as to prepare the copolymer containing a fluorine-containing compound side chain and a pyrocatechol-anchored radical side chain. The copolymer, on the one hand, has a pyrocatechol-anchored radical of dopamine to provide a good adhesive performance; one the other hand, the coplymer has the fluorine-containing compound radical, so that the copolymer has oil resistance, corrosion resistance and a hydrophobic and oleophobic property, and the protective performance of a functional protecting coating is extremely improved. The invention further discloses a functional protecting surface material with a good adhesive performance. The material is obtained by self-assembling the N-(3,4-dihydroxyl phenyl)ethyl-methacrylamide copolymer on the surface of the material by soaking. The material has a good protecting performance, a super-hydrophobic property, an antifouling capability and a adhesive performance; is wide in application range of a base; and is non-toxic and free of pollution.

The invention discloses an eight-membered nitrogen-oxygen heterocyclic spiro indolone compound and a preparation method thereof, and belong to the technical field of preparation of compounds. The method specifically comprises the following steps that vinyl ethylene carbonate and trifluoroethyl substituted isatin-3-imine serve as synthetic materials, a metal palladium catalyst, a phosphorus-contained ligand and an acid-base additive are added, and reaction is carried out at room temperature so as to obtain a product. The preparation method has the advantages of being mild in reaction conditions, high in reaction speed, simple in post-treatment and wide in application range and is a brand-new method for efficiently synthesizing the eight-membered nitrogen-oxygen heterocyclic spiro indolone compound with the potential bioactivity.

The invention discloses a synthesis method of a chiral spiro tetrahydrofuran pyrazolone compound, which specifically comprises the following steps: by taking vinyl cyclic carbonate and alpha, beta-unsaturated pyrazolone as reactants, Pd (PPh3) 4 as a metal and a chiral phosphorus ligand as a chiral ligand, reacting in an organic solvent to obtain the chiral spiro tetrahydrofuran pyrazolone compound. The method disclosed by the invention has the advantages of simple and easily available raw materials, mild reaction conditions, simple and convenient post-treatment, wide applicable substrate range, high yield and high enantioselectivity; the synthesized product can be used for synthesizing an intermediate of a medicine.

The invention discloses a synthesizing method of a chiral spiro oxindole dihydropyran derivative. The synthesizing method comprises the following steps of using dihydropyran (pyran) and isatin-derived beta,gamma-unsaturated alpha-keto ester as reaction matters; under the existence of a chiral (Box) / Cu(II) complex, synthesizing in a benzotrifluoride solvent to obtain a product. The synthesizing method disclosed by the invention has the advantages that the raw materials are simple, the obtaining is easy, the reaction condition is mild, the post-treatment is simple and convenient, the applicable substrate range is broad, the yield is high, and the enantioselectivity and non-enantioselectivity are high; the synthesized product has potential medical value.

The invention discloses an aza medium ring lactone compound and a preparation method thereof, and belongs to the technical field of compound preparation. According to the invention, the [5 + 6] cycloaddition reaction of vinyl ethylene carbonate and isatin anhydride is constructed for the first time,so that the chemical synthesis of aza medium ring lactone is efficiently and simply realized; specifically, vinyl ethylene carbonate and isatin anhydride are used as synthetic building blocks, a metal palladium catalyst and a phosphorus-containing ligand are added, and a target product is obtained through a reaction under a heating condition of 50-70 DEG C; the preparation method is simple to operate, quick in reaction, high in product yield, simple in aftertreatment and wide in substrate application range; and the synthesis method is a brand-new and efficient synthesis method of the aza medium ringlactone compound with potential biological activity and medicinal value.

The invention discloses a method for detecting the concentration of active components in a Grignard reagent solution. The method comprises the steps that 1, a standard aldehydes solution is prepared;2, a standard aldehydes solution is measured, the solution, in a first solvent, of a Grignard reagent is dropwise added into the standard aldehydes solution for a reaction for n hours, and then a quenching agent is added to obtain a first reaction solution; 3, a standard aldehydes solution is measured, the first solvent is dropwise added into the standard aldehydes solution, after n hours, a quenching agent is added to obtain a second reaction solution; 4, the first reaction solution and the second reaction solution which are equal in volume are selected and subjected to chromatographic detection under same detection conditions respectively, wherein the peak areas corresponding to aldehydes materials in the first reaction solution and aldehydes materials in the second reaction solution respectively are denoted as S1 and S2 respectively; 5, according to a computational formula, the concentration M of the active components in the solution, in the first solvent, of the Grignard reagent isobtained, wherein the computational formula is an equation, namely M=(1-S1 / S2)*X1*V1 / V2 mol / L. By means of the method, the technical problem can be solved that the concentration of the active components in the Grignard reagent solution is difficult to accurately detect.

The invention discloses a method for preparing olefin by deoxidizing and dehydrating a polyhydroxy compound by using an alcohol as a reducing agent. The method is characterized in that raw materials containing a polyhydroxy compound and a catalyst react in the presence of an alcohol reducing agent to obtain olefin. According to the method for deoxidizing and dehydrating a polyhydroxy compound by using primary alcohol, secondary alcohol, tertiary alcohol, benzyl alcohol and other alcohols are used as reducing agents, the alcohol reducing agent is cheap and environmentally-friendly, and has universality to the deoxidation dehydration reaction of the polyhydroxy compound.

Belonging to the technical field of compound preparation, the invention relates to a chiral barbital spiro tetrahydroquinoline compound and a preparation method thereof. The method specifically includes: taking a vinyl benzoxazinone compound and a barbital olefin compound as the reactants, also adding a metal palladium catalyst and a phosphorus-containing chiral ligand, and carrying out reaction at room temperature to obtain the product. The preparation method has the advantages of mild reaction conditions, fast reaction speed, simple post-treatment, and wide range of applicable substrates, and also most of the synthesized target compounds have high yield, excellent enantioselectivity and non-enantioselectivity. The method is a brand new method for efficient synthesis of chiral barbital spiro tetrahydroquinoline compound with potential medicinal value.

The invention discloses imidazolyl ionic liquid as formula I and a synthesizing method thereof. When the imidazolyl ionic liquid is applicable to Knoevenagel reactions, the imidazolyl ionic liquid has the advantages that imidazolyl ionic liquid is wide in applicable substrate range, short in reaction time, mild in reaction actions, and reusable.

The invention discloses a synthesis method of a chiral phosphorus-contained pyrazolone compound. The synthesis method concretely comprises the step: with pyrazolidinone imine and diaryl phosphorus oxide or dimethyl phosphite as a reactant, synthesizing the chiral phosphorus-contained pyrazolone compound in a solvent under the analysis of multifunctional chiral squaric acid amide. The method disclosed by the invention is simple and easy to obtain raw material, mild in reaction condition, simple and convenient for after-treatment, wide in applicable substrate range, high in yield and high in enantioselectivity; in addition, the chiral phosphorus-contained pyrazolone compound synthesized by using the method can be used for synthesizing an intermediate of a drug and an insecticide.

The invention discloses a chiral spiro pyrazolone compound and a preparation method thereof, and belongs to the technical field of compound preparation. Specifically, N, N '-cyclic imine 1, 3-dipole and pyrazolone exocyclic olefin are used as reactants, an additive and a solvent are added, a heating reaction is performed to obtain a product, and the structural formula is shown in the specification. The preparation method has the advantages of small additive dosage, short reaction time, simple post-treatment, wide substrate application range, and high yield and diastereoselectivity of most synthesized target substances. The method is a brand-new method for efficiently synthesizing the chiral spiro pyrazolone compound with potential medicinal value.

The invention discloses a N-(3,4-dihydroxyl phenyl)ethyl-methacrylamide copolymer and a preparation method therefor. By taking dopamine and a fluorine-containing compound as raw materials, the dopamine is modified by using the fluorine-containing compound by virtue of a copolymerization method so as to prepare the copolymer containing a fluorine-containing compound side chain and a pyrocatechol-anchored radical side chain. The copolymer, on the one hand, has a pyrocatechol-anchored radical of dopamine to provide a good adhesive performance; one the other hand, the coplymer has the fluorine-containing compound radical, so that the copolymer has oil resistance, corrosion resistance and a hydrophobic and oleophobic property, and the protective performance of a functional protecting coating is extremely improved. The invention further discloses a functional protecting surface material with a good adhesive performance. The material is obtained by self-assembling the N-(3,4-dihydroxyl phenyl)ethyl-methacrylamide copolymer on the surface of the material by soaking. The material has a good protecting performance, a super-hydrophobic property, an antifouling capability and a adhesive performance; is wide in application range of a base; and is non-toxic and free of pollution.

The invention discloses a 2-phosphonyl-3-fluoro vinyl indole compound which is complex and diverse in structure, contains phosphonyl, an indole ring and fluoro vinyl, can be subjected to further structural modification and serves as an important intermediate for organic synthesis. After the phosphonyl is reduced into trivalent phosphine, the trivalent phosphine can also be used as an important phosphine ligand to participate in organic synthesis reaction catalyzed by transition metal and the like. According to the synthetic method of the 2-phosphonyl-3-fluoro vinyl indole compound, in the air atmosphere, a difluoromethyl indole methanol compound and a disubstituted phosphine oxide compound serve as raw materials and react in a solvent, and the method is simple, free of any catalyst, environmentally friendly, mild in reaction condition, high in yield and wide in reaction substrate range. The 2-phosphonyl-3-fluoro vinyl indole compound disclosed by the invention can be used as a ligand and an organic synthesis intermediate, and has a wide application prospect.

Five-membered and six-membered carbon ring chiral oxindole spiro skeletons widely exist in active natural products and drug molecules, and development of a high-efficiency synthesis method of the chiral spiro compounds and analogues thereof will promote development of new drugs. Indolone which is cheap and easy to obtain and an amphiphilic electroalkylating reagent are adopted as raw materials, novel and efficient [4 + 1] and [5 + 1] cyclization reactions are developed under the condition of asymmetric phase transfer catalysis, and therefore general synthesis of chiral oxoindole spiro rings containing five-membered and six-membered carbon rings can be rapidly constructed in one step, and the chiral oxoindole spiro rings containing five-membered and six-membered carbon rings can be obtained. And the one-step synthesis of the key chiral spiro intermediate of the medicine ubrogepant is realized. The method is mild in reaction condition and simple in process, the target compound can be obtained without water-free and oxygen-free operation, the requirement for production equipment is low, the substrate application range is wide, and the method has extremely high industrial application value.

The invention discloses a solid self-lubricating coating and a preparation method thereof.The coating is formed by compounding a hard diamond-like phase serving as an intrinsic supporting layer and a soft graphitization phase serving as a surface lubricating layer, the hard diamond-like phase is formed by mixing sp2 and sp3 hybrid carbon structures, and the atomic percentage content of sp3 is 25-70%; the soft graphitized phase is mainly composed of an sp2 hybrid carbon structure, the atomic percentage content of sp2 is 90% or above, and the content of a six-membered ring structure is 60% or above; the composite lubricating coating has the advantages of high hardness, high bearing capacity, low abrasion, super-lubricity and friction coefficient lt; 0.01, the solid self-lubricating coating material can provide wear-resistant lubricating protection for a matrix or a workpiece in various environments such as high load and high speed, the preparation method is simple, the operability is high, industrial production is easy, and the solid self-lubricating coating material is excellent in comprehensive performance, long in service life and high in reliability.

The invention discloses a light absorption coating film. The light absorption coating film is a titanium aluminum nitrogen coating film and comprises a bottom layer and an outer layer, wherein the bottom layer is of a nano-layered structure, the outer layer is of a columnar crystal structure, the top end of the columnar crystal structure is a conical surface, in the wavelength range of the light wave ranging from 200 nm to 2500 nm, the average light absorption rate alpha of the light absorption coating film is not less than 0.89, after the TiAlON or TiO2 or SiO2 antireflection layer is added on the outer layer of the light absorption coating film, the average light absorption rate alpha of the light absorption coating film in the wavelength range of the light wave ranging from 200 nm to 2500 nm is not less than 0.95, the light absorption coating film has the advantages that the light absorption frequency range is wide, the absorption rate is high, the coating physical and chemical properties are stable and the like. The invention further discloses a preparation method and application of the light absorption coating film. According to the method, the raw material cost is low, a substrate and the coating process do not need to undergo other special treatment, the process is simple and convenient, large-area preparation can be realized, the light absorption coating film prepared by the method is controllable in structure, and coating on the surfaces of different materials can be realized.

The invention provides a method of catalyzing trifluoro-ethylation of aromatic secondary amine by ferriporphyrin. The method comprises the following steps: adding trifluoroethylamine salt and nitriteto a diazo-reaction first and then adding aromatic primary amine and a ferriporphyrin catalyst for a trifluoro-ethylation reaction to obtain a trifluoro-ethylated aromatic secondary amine compound inan acidic solution system. The reactions of the method are carried out at room temperature, and the reaction condition is mild, and an intermediate product is not separated through a one-pot reaction.The method is few in reaction step, simple to operate, wide in application range of primers, wide in source of raw materials and high in yield of reaction products.

The invention relates to a synthetic method for 2-methyl-4-carbonyl-2,4-diphenyl butyraldehyde. The synthetic method comprises the following steps: firstly adding 1,1-dimethoxy-N,N-dimethyl methylamine into a methylbenzene solution of acetophenone, after stirring and performing a heating reaction, quenching a product with water, and then carrying out extraction, drying and purification to obtain (E)-3-(dimethyl amino)-1-phenylprop-2-ene-1-ketone; slowly dropwise adding acetophenone into a methanol solution of p-toluenesulfonhydrazide to obtain p-toluenesulfonylhydrazone; and carrying out a reaction on (E)-3-(dimethyl amino)-1-phenylprop-2-ene-1-ketone, p-toluenesulfonylhydrazone, copper hydroxide and potassium carbonate in argon shield, and purifying a reaction product to obtain 2-methyl-4-carbonyl-2,4-diphenyl butyraldehyde. The method is wide in substrate application range, the tolerance for various functional groups is high, cheap copper is taken as a catalyst, and the reaction condition is mild; and a synthetic 1,4-ketoaldehyde compound can be easily converted into various useful synthetic structures, and carries an alpha-quaternary three-dimensional center.

The invention discloses an ultralow-friction solid-liquid composite lubricating coating and a preparation method thereof, and belongs to the technical field of material surface coating. The diamond-like coating is arranged on two or more base bodies with the mutual friction working condition, the diamond-like coating is arranged on the friction face where the base bodies rub with each other, and a lubricating oil layer serving as an intermediate liquid phase is arranged between the diamond-like coatings of the two or more base bodies with the mutual friction working condition. Only the surface of the diamond-like carbon coating is hydrogenated, and the percentage content of H element atoms contained in the hydrogenated surface is 3%-38%. The diamond-like solid phase has high hardness, good toughness and good bearing performance, and the formed solid-liquid composite lubricating coating has extremely low friction coefficient (0-0.01) and wear rate, so that the diamond-like solid phase composite lubricating coating is a composite lubricating coating material with excellent comprehensive performance, long service life and high reliability.

The invention discloses a synthesis method of a 2, 3-diamino indole compound, which belongs to the technical field of chemical synthesis, and comprises the following operation steps: adding o-ethynylaniline, arylamine, lithium perchlorate, tetrabutylammonium iodide and tetramethylpiperidine oxide into a three-necked bottle, finally adding a solvent, under the condition of electrification, taking a platinum electrode as an anode, and reacting for 2-4 hours to obtain the 2, 3-diamino indole compound. The preparation method comprises the following steps: by taking an organic solvent as a cathode and a carbon electrode as a cathode, stirring and reacting for 8-12 hours under a constant-current condition, after the reaction is finished, extracting reaction liquid, carrying out rotary evaporation on the extracted reaction liquid, and carrying out silica gel column chromatography separation to obtain a target product, according to the method, metal catalysis is not needed, the reaction can be carried out at normal temperature, mild reaction can be carried out in a solvent system of water and acetonitrile, the method is particularly suitable for synthesis of some drugs, the problems of metal residues and the like are fundamentally solved, and high economic applicability is achieved; the problems that expensive transition metal is basically used and higher reaction temperature is needed in the existing method are solved.

To solve the problem that an excellent carrier material is absent in a storage and use process of the bone morphogenetic protein, based on self-polymerization universality of dopamine, the positively-charged polyelectrolyte, the negatively-charged polyelectrolyte and the ceramic powder with biological activity are integrated onto the titanium base material in a layer-by-layer assembly mode to construct a bone morphogenetic protein slow-release system, so that long-acting slow release, on a lesion part, of the bone morphogenetic protein is achieved. The slow-release system has the advantages of being high in surface modulus, stable, resistant to radiation, good in biocompatibility, and the like, can effectively promote osteogenic differentiation of the mesenchymal stem cells, and can be expected to effectively promote bone repair.

The invention provides a method of catalyzing trifluoro-ethylation of aromatic secondary amine by ferriporphyrin. The method comprises the following steps: adding trifluoroethylamine salt and nitriteto a diazo-reaction first and then adding aromatic primary amine and a ferriporphyrin catalyst for a trifluoro-ethylation reaction to obtain a trifluoro-ethylated aromatic secondary amine compound inan acidic solution system. The reactions of the method are carried out at room temperature, and the reaction condition is mild, and an intermediate product is not separated through a one-pot reaction.The method is few in reaction step, simple to operate, wide in application range of primers, wide in source of raw materials and high in yield of reaction products.