4results about How to "Less research" patented technology

The invention provides application of a metabolite S-cysteine succinic acid (S-Cysteinosuccinic acid) as a molecular marker for diagnosis and prognosis of lung cancer brain metastasis tumors, and application of a reagent for detecting the metabolite in preparation of a reagent for diagnosis and prognosis of the lung cancer brain metastasis tumors. The invention further provides a method for evaluating the occurrence risk of the lung cancer brain metastasis tumor, and the method comprises the steps that subjects are divided into a high-risk group of the lung cancer brain metastasis tumor and a low-risk group of the lung cancer brain metastasis tumor according to the expression level of metabolites in samples of the subjects, and the metabolites comprise S-Cysteinosuccinic acid. The invention also relates to a kit or a chip containing the reagent for detecting the metabolite.

The invention discloses a phenolic acid inhibitor and a use method and application thereof.The phenolic acid inhibitor comprises a component A. The component A comprises phenolic acid, polyethylene glycol and a phosphate buffer solution, and the phenolic acid is one or more of cumaric acid, kojic acid, chlorogenic acid, gallic acid and ferulic acid; the phenolic acid inhibitor is prepared from the following raw materials in parts by weight: 1 to 3 parts of phenolic acid, 0.1 to 0.3 part of polyethylene glycol and 8 to 12 parts of phosphate buffer solution, and the phenolic acid is two or three of coumaric acid, chlorogenic acid and ferulic acid. The PPO inhibition activity of the phenolic acid inhibitor can reach 70%-80%, the quality of fruits is well maintained, and browning caused by fruit processing is delayed.

The present invention provides the use of α-pineneol as a synergist in combating drug-resistant Enterobacteriaceae, and belongs to the field of medical technology. Specifically, α-pineneol is used as a synergist in combination with colistin or β-lactam antibiotic meropenem to combat drug-resistant Enterobacteriaceae; the drug-resistant Enterobacteriaceae include drug-resistant Salmonella, drug-resistant Escherichia coli, and drug-resistant Klebsiella pneumoniae. The present invention provides a new use of the natural compound α-pineneol: α-pineneol can effectively enhance the sensitivity of drug-resistant Enterobacteriaceae to carbapenem antibiotics meropenem and colistin, and effectively improve the efficacy of the above-mentioned antibiotics on drug-resistant Enterobacteriaceae, which is of great significance for solving clinical drug-resistant Salmonella, drug-resistant Escherichia coli and drug-resistant Klebsiella pneumoniae infections. Provide safe and effective auxiliary drugs for the treatment of drug-resistant Enterobacteriaceae infection diseases and provide technical support for the control of bacterial resistance.

The application discloses a quick well killing method without drill bit at well bottom, and relates to the technical field of well control of oil drilling. First, basic data is collected, initial state calculation of well killing is carried out according to the collected basic data, then suitable well killing fluid density is designed according to the initial state, casing pressure is adjusted so that the well killing fluid is divided at the drill bit, well killing parameters are designed through the well state, well killing progress is judged through the standpipe pressure and the casing pressure, and well killing is finished after the contaminated drilling fluid is completely discharged through circulation of the well killing fluid. The application proposes the quick well killing method without drill bit at well bottom, which has certain guiding significance for well killing in the case that the drill bit is not at the well bottom.