The invention discloses a formula for preventing wrinkle, removing beverage and retarding skin aging, and relates to the technical field of medicines. The formula comprises the following components: 30g of polygonum multiflorum, 30g of radix astragali, 30g of pseudo-ginseng, 15g of rhodiola rosea, 15g of gynostemma pentaphyllum, 10g of American ginseng, 50g of radix angelicae, 50g of atractylodes macrocephala, 30g of bletilla striata, 30g of rhizoma typhonii, 30g of poria cocos, 30g of stiff silkworms, 15g of honeysuckle, 30g of radix scrophulariae, 30g of leonurus artemisia, 30g of radix ophiopogonis, 30g of chrysanthemum, 0-30g of abrus cantoniensis hance, 0-30g of selfheal, 30g of loranthus parasiticus, 0-30g of caulis spatholobi, 0-30g of angelica sinensis, 30g of lycium barbarum, 30g of carthamus tinctorius, 30g of rehmannia glutinosa, 15g of lithospermum, 0-20g of acacia catechu, 20g of rheum officinale, 30g of white paeony roots, 30g of ligusticum wallichii, 0-30g of gastrodia elata, 0-20g of acanthopanax roots, 0-30g of crocus sativus, 30g of witch hazel, 0-30g of arbutin, 0-30g of salvia japonica, 0-30g of ginseng, 0-30g of aloe, 30g of calendula, 0-10g of pearl powder and 0-10g of fructus cannabis. The formula is capable of preventing wrinkle, removing beverage and retarding skin aging and is free of side effects, good in use effect and low in cost.