The invention discloses a variable-supporting-diameter seamless forming drum. The variable-supporting-diameter seamless forming drum comprises a shaft sleeve, a guide disc, a guide key disc, a movablebase, a power mechanism, floating connecting rod bases, springs, guide rods, fixed connecting rod bases, large locking blocks, small locking blocks, sliding blocks, first connecting rods, second connecting rods, a limiting ring and a limiting ejector rod, wherein the shaft sleeve, the guide disc and the guide key disc are fixedly connected together; the power mechanism drives the movable base toslide along the shaft sleeve, and pushes the floating connecting rod bases and the fixed connecting rod bases to move synchronously; and the large locking blocks and the small locking blocks are driven by the connecting rods to move outwards in the radial direction of the guide key disc. When a sliding sleeve makes contact with the limiting ring, the sliding sleeve stops moving, the large lockingblocks stop moving accordingly, the movable base continues to push the fixed connecting rod bases to move, and the small locking blocks continue to move outwards till the small locking blocks and thelarge locking blocks jointly define a locking circle. Moreover, the position of the limiting ring can be adjusted by adjusting the limiting ejector rod, and locking circles with different diameters can be formed, so that locking of tire blanks with different seam allowance inner diameters is met.