The invention discloses a special disease-resistant and drought-resistant yield-increasing fertilizer for large peaches. The fertilizer comprises the following components: soy meal, dry duck manure, urea, ammonium chloride, calcium nitrate, diammonium phosphate, potassium chloride, magnesium sulfate, zinc sulfate, sodium selenate, ammonium molybdate, copper sulfate, zeolite, vermiculite, fly ash, malic acid, tartaric acid, sodium humate, phosphate solubilizing bacteria, cyanoguanidine, N-butyl thiophosphoric triamide, polyacrylamide, brassinolide and gibberellin. The special disease-resistant and drought-resistant yield-increasing fertilizer for large peaches contains various nutritional components, is reasonable in formula and suitable for the growth of large peaches, and is used for a peach planting process, various nutrients can be fully utilized, the disease resistance and drought resistance of large peaches are improved, and the quality of large peaches is improved.