The invention discloses globe artichoke digestion powder and a preparation method thereof. The globe artichoke digestion powder contains globe artichoke, urtica fissa, radix prismatomeris connata, milfoil, chamomile, fennel, fructus amomi rotundus, dandelion, citrus peel and fructose. The preparation method comprises the following steps: mixing globe artichoke, urtica fissa, milfoil, chamomile anddandelion, and grinding the mixture into slurry; drying radix prismatomeris connata, fennel, fructus amomi rotundus and citrus peel, and crushing, so as to obtain a crushed material; putting the crushed material and fructose into the slurry, and stirring, so as to obtain a mixture; sterilizing the mixture; and carrying out spray drying on the sterilized mixture, so as to obtain the globe artichoke digestion powder. According to the globe artichoke digestion powder provided by the embodiment of the invention, the raw materials are natural foods, and the globe artichoke digestion powder does not contain any additive, can be directly eaten and brewed with water to be drunk and is suitable for being eaten by different crowds; and by matching globe artichoke, urtica fissa, milfoil, radix prismatomeris connata, dandelion and citrus peel, the globe artichoke digestion powder has the efficacies of promoting gastrointestinal motility, whetting appetite and promoting digestion.