3 results about "Immunologic Procedures" patented technology

Provided are a Trichinella spiralis vaccine kit based on a prime-boost sequential immunization program and use thereof, improving the protective effect against trichinosis. The kit is divided into two parts; the first part is a Trichinella spiralis recombinant protein vaccine having an amino acid sequence set forth in SEQ ID NO. 1 or SEQ ID NO. 2, and the second part is a recombinant adenovirus expressing an amino acid sequence set forth in SEQ ID NO. 1. The prime-boost immunization strategy not only effectively avoids the deficiency associated with a single-type Trichinella spiralis vaccine, but also significantly improves the efficacy and durability of the immune response.

Provided are a rabies virus G protein mutant, a preparation method and application thereof, and relate to the technical field of biological medicine. The rabies virus G protein mutant is obtained by point mutation on the extracellular domain of the G protein. The mutant realizes soluble expression of the extracellular domain of the G protein, and can induce production of high-titer neutralizing antibodies. Compared with commercial human rabies vaccine and canine rabies vaccine, the mutant has more excellent cellular immune and antibody immune responses, and is expected to reduce the number of inoculations, shorten the immunization program and reduce the immunization dose.

The application provides a kind of preventive inoculation information quick entry and check device, relating to medical information technology field, including information collection registration module, database storage module, central check processing module, interactive alarm module and inoculation execution confirmation module;The application obtains the identity of the recipient and vaccine information through multi-modal mode, and encapsulates into standardized data packet, avoids the problem of low efficiency of manual entry, then the central check processing module carries out real-time, multi-dimensional logical reasoning calculation based on dynamic rules, and the back-end operation and management indexes such as cold chain quality and inventory status are preposed as real-time check dimensions as important as medical contraindications and immunization programs, so that the use of invalid vaccine, inventory shortage misregistration and other difficult to prevent risks are actively intercepted before inoculation occurs, and further, the man-machine collaborative decision mechanism of alarm state is introduced, which ensures that the safety bottom line is not broken, and gives the final decision-making right to medical staff in complex situation.