The invention relates to a PC / ABS alloy material with excellent chemical substance resistance, and a preparation method thereof. The PC / ABS alloy material comprises, by weight, 60-80 parts of silicon-containing PC resin, 15-40 parts of ABS resin, 5-25 parts of PMMA resin, 0.1-5 parts of a flexibilizer, 0.1-1 part of an antioxidant and 0.1-1 part of a lubricant. The preparation method comprises the following steps: 1, adding the silicon-containing PC resin, the ABS resin, the PMMA resin, the flexibilizer, the antioxidant and the lubricant into a mixing stirrer, and mixing all added materials; and 2, feeding a mixture obtained in step 1 to a double screw extruder through a main feeding opening, and carrying out blend granulation to prepare the PC / ABS alloy material with excellent chemical substance resistance. The silicon-containing PC resin with excellent chemical substance resistance is used, the PMMA resin is added, and the PMMA in a molten state has a lower viscosity than the PC and the ABS and can easily aggregate on the surface of a product in the injection molding process to form a protection layer on the surface of the product in order to improve the chemical substance resistance of the PC / ABS resin.