The invention discloses a self-cleaning material for signal lines. The self-cleaning material is prepared from the following ingredients, by weight, 30-40 parts of hydroxyl-terminated fluorine-containing polyester polysiloxane, 10-20 parts of chitosan- adipic acid dual coating modified calcium carbonate, 40-60 parts of diisocyanate fluoride, 20-30 parts of a PS-b-PDMS-b-PS segmented copolymer, 10-15 parts of POE-g-MAH and 15-25 parts of a processing aid. The invention also discloses a preparation method of the self-cleaning material for signal lines. The product has characteristics of low surface tension of fluoroalkyl-containing and siloxane-containing structures, hydrophobicity, oleophobicity and the like. When the product is applied to signal lines, the product has advantages of self-cleaning function, high anti-pollution ability, flexibility, good elasticity, good hand feeling, good weatherability, chemicals resistance, antibacterial property and the like, and is not easy to scratch or leave a trace. When in use, the product can keep bright in appearance for a long time. thus, the defect that most existing fluorine-containing materials have high hardness and inflexible molecular chain and are not applicable to signal lines is overcome.