The invention discloses a NiCrNb-Re high-temperature-resistance and corrosion-resistance welding wire for ethylene cracking furnace cast pipes and a preparation method thereof, and belongs to the field of welding materials. The welding wire comprises the following components in percentage by weight: 45-50% of Ni, 35-40% of Cr, 1.00-1.50% of Nb, 0.01-0.10% of Re, 0.30-0.55% of C, 0.50-2.00% of Si,1.00-2.00% of Mn, 0.01-0.10% of Al, 0.05-0.20% of Ti, 0.01-0.10% of Zr, and the balance of Fe and inevitable impurities. The preparation method comprises the steps of alloy smelting-electroslag remelting-blooming by hot forging-hot-rolled annealing-mechanical stripping-diameter reduction by drawing-straightening and cutting or precise layer winding. The preparation method is environmentally friendly, free of acid washing pollution, stable in welding arc, free of splashing, beautiful in welding line molding, excellent in welding process and mechanical performance and dense in welding line structure, and can totally meet high-temperature-resistance and corrosion-resistance welding requirements of the ethylene cracking furnace cast pipes.