The invention relates to a thermal treatment technology of a large-size high-strength wrought magnesium alloy forging, and particularly relates to a thermal treatment technology of a wrought magnesium alloy forging of an Mg-Al-Zn system. The implementation scheme of the invention is as follows: preserving heat of the large-size wrought magnesium alloy forging with the wall thickness of 30-100mm, the diameter (phi) of greater than or equal to 680mm and the maximum horizontal projection area of greater than or equal to 0.4m<2> at 80-100 DEG C for 36-48 hours; heating to 160-180 DEG C at a rate of 15-30 DEG C per hour, and preserving heat for 15-20 hours; and cooling to room temperature to obtain the large-size high-strength wrought magnesium alloy forging, wherein the magnesium alloy forging comprises the following elements in percentage by mass: 8.2-8.5% of Al, 0.4-0.5% of Zn, 0.2-0.25% of Mn, less than or equal to 0.05% of Cu, less than or equal to 0.005% of Ni, less than or equal to 0.15% of Si, less than or equal to 0.02% of Be, less than or equal to 0.05% of Fe, less than or equal to 0.3% of other impurities and the balance of Mg. By adopting the technology provided by the invention, the prepared large-size high-strength wrought magnesium alloy forging can meet the using requirements for the parts of the fields of transportation, aerospace and the like; and the preparation technology is simple and easy to implement, and industrial production is facilitated.