The invention relates to the technical field of steel plate spring machining, in particular to a high-stress and long-service-life variable section single steel plate spring and a manufacturing methodthereof. The high-stress and long-service-life variable section single steel plate spring comprises a single steel plate spring body which is high-strength spring flat steel, wherein the tensile strength of the high-strength spring flat steel is larger than or equal to 1,870 MPa, and the yield strength is larger than or equal to 1,680 MPa; after forming, the section of the variable section singlesteel plate spring is in a parabola shape changing in the length direction of the variable section single steel plate spring, and front-back symmetry and left-right symmetry are achieved with a center bolt hole as the center. The manufacturing method of the high-stress and long-service-life variable section single steel plate spring comprises the procedures of material breakage, center hole machining, heating, variable section forming, lug rolling, forming heat treatment, shot blasting, electrophoresis paint spraying and warehousing. Through two-time shot blasting including free shot blastingand high-stress shot blasting, the residual compressive stress of the surface of the stretching side of the single spring is improved. The high-stress and long-service-life variable section single steel plate spring is simple in structure, and the single steel plate spring manufacturing process is simplified; and meanwhile, the bearing capability is improved, the vehicle lightweight design requirement is met, the tensile fatigue strength of the single steel plate spring is improved, and the fatigue life of the single steel plate spring is prolonged.