The invention belongs to the technical field of cables and particularly relates to a submarine high-pressure cable. The submarine high-pressure cable is composed of a conductive unit, a metal shielding layer, a water retention layer, an inner protecting bush, an armor layer, an outer protecting bush and an outer protecting bush protection layer; the conductive unit is composed of a conductor, an insulating layer, an insulation shielding layer and a conductor protecting layer, on any cross section, the circle center of the conductor coincides with the circle center of the insulating layer, the diameter of the insulating layer is 1.5-5 times that of the conductor, and the minimum value of the insulating layer thickness is 1.5 mm; filling rope groups and reinforcing piece groups are distributed outside the inner protecting bush in an alternate mode, and both the filling rope groups and the reinforcing piece groups are tightly attached to the inner protecting bush; the outer protecting bush protection layer is made of polyamide; the insulating layer is made of organosilane crosslinked polyethylene or a special material. The invention further discloses a manufacturing method of the submarine high-pressure cable. The submarine high-pressure cable and the preparation method thereof have the advantages that mechanical property redundancy is more proper, more resources are saved, wear resistance is better, water seepage performance is better, seawater resistance is better, shielding performance is better, and high voltage can be transmitted better.