The invention discloses a compound fermentation blueberry health-care wine and a production technology thereof. Blueberry, blueberry leaves, medlar and bran are selected as raw materials to produce the compound fermentation health-care wine by a compound fermentation production technology, wherein the compound fermentation liquid comprises the following components in proportion: 17-23% of blueberry leaf extracting solution, 6-10% of blueberry juice, 10-15% of medlar juice and 55-65% of bran saccharification liquid. The product is high in nutrient value, basically preserves the natural nutritional components in the blueberry and the blueberry leaves, contains nutrient substances such as anthocyanin and vitamin which are necessary to a human body, and has the effects of improving eyesight, eliminating eye fatigue, nourishing the skin, moistening lung, tonifying spleen and nourishing stomach, delaying cranial nerve ageing, preventing capillaries diseases, enhancing cardiac function, preventing senile dementia, fighting fatigue and the like. The compound fermentation blueberry health-care wine has the advantages that 1, an ultrasonic assisted extraction technology is adopted, and the extraction rate of the active substances is high due to the fermentation effects of microorganisms; 2, the nutrient level of the blueberry health-care wine is improved by virtue of compound fermentation of the blueberry, the blueberry leaves, the medlar and the bran; 3, the product is high in clarity, good in sterilization and impurity removal effects, and small in nutrient loss of product by adopting a microporous membrane filtering production technology, and the traditional pasteurization is replaced.