The present invention belongs to the health-care field of traditional Chinese medicines, specifically relates to the health-care field of the traditional Chinese medicines, and specifically relates tomind-refreshing and fatigue-preventing traditional Chinese medicinal drink and a preparation method thereof. A formula of the traditional Chinese medicinal drink is characterized by comprising main medicines and auxiliary materials. The main medicines of the traditional Chinese medicinal drink consist of the following traditional Chinese medicines: burdock roots, yacon leaves, spirulina platensis, herba cistanche, dried ginger, Chinese prickly ash, royal jelly, longan meat, radix acanthopanacis semticosi, fiveleaf gynostemma herbs, fructus amomi, pericarpium citri reticulatae viride, chicken's gizzard-membranes, wrinkled gianthyssop herbs, rhizoma alismatis, semen ziziphi spinosae, radix paeoniae rubra, rhizoma chuanxiong, coix seeds, radix aconiti carmichaeli, haws, malts, bulbus lilii,mulberries, flos sophorae, orange peels, blueberries, flos carthami and semen euryales. The auxiliary materials comprise a sweetener, an acidity regulator, a preservative and a stabilizer. The traditional Chinese medicinal drink can effectively refresh mind and prevent fatigue, is more easily accepted by applicable populations, and improves patient consumption compliance.