The invention belongs to the field of traditional Chinese medicine health care, in particular to a traditional Chinese medicine beverage for refreshing and anti-fatigue and a preparation method thereof. It is characterized in that the formula of the traditional Chinese medicine beverage includes the main medicine and auxiliary materials, and the main medicine of the Chinese medicine beverage is composed of the following traditional Chinese medicines: burdock root, yagon leaf, spirulina, cistanche, dried ginger, pepper, royal jelly, longan meat, Acanthopanax, Gynostemma, amomum, green skin, gallinacea, ageratum, alisma, jujube seed, red peony root, chuanxiong, coix seed, aconite, hawthorn, malt, lily, mulberry, sophora japonica, orange peel, blueberry, safflower, gorgon ; Excipients include sweeteners, acidity regulators, preservatives, stabilizers. The traditional Chinese medicine beverage can quickly and effectively refresh the mind and resist fatigue, and is more easily accepted by applicable people, thereby improving the compliance of patients in taking it.