The invention is applied to the field of health wine, and particularly relates to ganoderma lucidum health wine and a preparation method thereof. The ganoderma lucidum health wine is brewed from ganoderma lucidum, ginseng, Chinese yam, Angelica sinensis, cynomorium songaricum, mulberry leaf and prepared sorghum as a base material. The ganoderma lucidum health wine is rich in amino acids, organic germanium, selenium, ganoderma lucidum polysaccharide, calcium, magnesium, sodium, iron and other nutritional ingredients beneficial for human health, and is capable of tonifying the liver and kidney, nourishing yin and nourishing the blood, removing heat from the liver and improving eyesight, improving sleeping, enhancing human immunity and preventing diseases. In addition, the ganoderma lucidum wine is white in color, clear and transparent, and pure and natural in vinosity, has fresh and sweet flavor peculiar to sweet ganoderma lucidum liquid, also has alcohol aroma of the traditional sorghum liquor, has no bitterness and astringency of the traditional ganoderma lucidum wine, and has a drug effect without medicinal odor. The ganoderma lucidum wine has the characteristics of no sedimentation, no color change, and softness and subtle fragrance in mouth after long-year aging.