The invention belongs to the technical field of semiconductor optic electronics and particularly discloses a stain-balance active-area gradient potential well layer semiconductor laser structure. The structure comprises a buffer layer, a lower matching layer, a lower limiting layer, a lower transition layer, a lower waveguide layer, a multiple-quantum well layer, an upper waveguide layer, an upper transition layer, an upper limiting layer, an upper matching layer and an electrode contact layer which are in sequential epitaxial growth from top to bottom by adopting a metal-organic chemical vapor deposition method. Improvements are performed on lowering threshold current of a laser, increasing output power, improving photoelectric conversion efficiency, prolonging service life, improving reliability and the like to obtain the semiconductor laser with the novel structural material system on the basis of improving quality of a material mutation heterogeneous interface of the multiple-quantum well layer, lowering mismatching ratio of strain of lattice constant, reducing mismatching ratio of total accumulated strain of an active area of a quantum well and avoiding lattice relaxation occurring to the quantum well heterogeneous interface.