The invention relates to an industrial sulfanilamide production system, which includes a sulfonation kettle, an acetanilide feed pot, a chlorosulfonic acid metering tank, a sulfonated oil metering tank, a first kettle, a water metering tank, a first oil standing tank, a second kettle, a recycling acid tank, a belt type centrifuge, a pulping kettle, an air supply device, a vacuum buffer tank, an ammoniation kettle, a liquid ammonia metering tank, a steam supply device, a hydrolysis kettle, a liquid caustic soda metering tank, an ammonia separation tank, a crystallization kettle, a hydrochloric acid metering tank, a centrifuge, a cyclone dryer, a circulating water cooling device, and a distributed control system. Through overall transformation of the production system, the industrial sulfanilamide production system provided by the invention can be controlled by the distributed control system, improves the automatic control level and safety performance, improves product quality and makes the product quality stable, reduces the operation intensity of workers, improves the on-site operation environment, saves energy and reduces emission, downsizes staff and improves efficiency.