The invention discloses a low-cost large-heat-input-weldable high-toughness steel plate and a manufacturing method thereof. According to the low cost large-heat-input-weldable high-toughness steel plate and the manufacturing method thereof, metallurgical technical means of taking a component system of micro-alloyed steel with low C and high Mn-(Nb+Ti) as a basis, controlling the cold cracking welding sensitive index Pcm to be not higher than 0.22%, appropriately increasing the content of acid-dissolved Als, controlling the ratio of Mn/C to be 25-55, carrying out Ni+high Cr alloying, controlling [(%C)+(%Mn)/6]*(%Si) to be not greater than 0.035, controlling (%Mn equivalent)*(%Cr equivalent) to be not smaller than 2.7, carrying out Ca treatment, controlling Ca/S to be 0.80-3.00, controlling Ti/N to be 1.5-3.0 and the like are adopted, and a TMCP (Thermo-Mechanical Control Process) and a tempering process are optimized, so that the microstructure of a finished steel plate is of fine bainite, the average crystal group size is smaller than 15 microns, the steel plate can bear large-heat-input welding while uniform and excellent mechanical properties are obtained and the toughness and the plasticity are matched, and then, the low-cost large-heat-input-weldable high-toughness steel plate is particularly applicable to engineering machinery, bridge structures, offshore oil production platforms, oil storage tanks and the like.