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126 results about "ESR - Electron spin resonance" patented technology
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Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy is a method for studying materials with unpaired electrons. The basic concepts of EPR are analogous to those of nuclear magnetic resonance (NMR), but it is electron spins that are excited instead of the spins of atomic nuclei.
Nanoparticulate probe for in vivo monitoring of tissue oxygenation
ActiveUS20070041909A1Organic chemistryMicrobiological testing/measurementPhthalocyanine derivativesMicro nanoparticles
A new class of micro- and nano-particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
Owner:THE OHIO STATE UNIV RES FOUND
Tunable microwave resonator for static dynamic nuclear polarization (DNP)
InactiveUS20160334476A1Measurements using magnetic resonanceMagnetic variable regulationSelective reflectionProton resonance frequency
A tunable millimeter-wave (mmw) DNP probe head is disclosed that is compatible with efficient H / X / Y / e− DNP in samples that may have volume large compared to λ03, where λ0 is the free-space wavelength at the frequency fe of the electron paramagnetic resonance (EPR) when placed in an external polarizing field B0, where B0 is typically in the range of 6.5 T to 35 T, corresponding to fe in the range of 180-1000 GHz, and corresponding to proton resonance frequency fH in the range of 280 MHz to 1500 MHz. The probe head comprises a tune cavity of adjustable volume, a sample cavity that is large compared to the sample wavelength, a tapered conical feed transition filled with a high dielectric material at the small end, and a selectively reflective wall that is substantially reflective of electromagnetic radiation at fe but substantially transparent to electromagnetic radiation at fH.
Owner:DOTY SCI
Method for detecting free radical ration in coal tar
InactiveCN103105409AOptimizing Assay ConditionsSolve the problem of low free radical contentAnalysis using electron paramagnetic resonanaceDPPHTar
The invention discloses a method for detecting free radical ration in coal tar. The method comprises the steps of removing moisture in the tar in a high speed centrifuging manner, and preserving a tar sample under low temperature or inert atmosphere; adopting a diamagnetism substance to deliquate DPPH(1,1-Diphenyl-2-picrylhydrazyl radical 2,2-Diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl) to prepare a plurality of DPPH standard samples with different free radical concentrations, carrying out EPR (electron paramagnetic resonance) measurement, carrying out secondary integration on an EPR spectrogram, and recording the corresponding secondary integration area; establishing a standard curve according to the free radical contents of the DPPH standard sample with different free radical concentrations and the secondary integration area of the corresponding EPR spectrogram; and filling the tar sample into a pipe, measuring according to the same EPR measuring condition, carrying out secondary integration on the measured EPR spectrogram, and substituting the secondary integration area into the standard curve so as to obtain the free radical content N. The method provided by the invention can exactly measure free radical content in coal tar, meanwhile, the change of the content of the free radical in the coal tar along with the preservation condition is exactly measured, and the method for detecting ration is provided for the research of the free radical in the coal tar and is very simple and easy.
Owner:EAST CHINA UNIV OF SCI & TECH
Dectecting melanoma by electron paramagnetic resonance
InactiveUS20050288573A1Measurements using electron paramagnetic resonanceDiagnostic recording/measuringMelanocyteSentinel lymph node
Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to image a melanoma. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to detect metastatic melanoma in a sentinel lymph node. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to measure light penetration in melanocytes in skin.
Owner:STC UNM
Nanoparticulate probe for in vivo monitoring of tissue oxygenation
Owner:THE OHIO STATE UNIV RES FOUND
Epr using frank sequence
ActiveUS20110210737A1Magnetic property measurementsMeasurements using electron paramagnetic resonanceSpinsExcitation signal
Various systems and methods for detecting electron spins using electron paramagnetic resonance are described. An excitation signal generator configured to generate an excitation signal of varying amplitude and phase as compared to a reference signal may be present. A crossed loop resonator configured to isolate a detection signal produced by the excitation signal exciting an object with a magnetic field may also be preset. Further, a detection device configured to detect electron spins of the object using the detection signal isolated by the crossed loop resonator may be present.
Owner:COLORADO SEMINARY
Polyphenol-based coordination polymer nano-particle and preparation method thereof
InactiveCN107441513AEasy to makeMild conditionsEnergy modified materialsGeneral/multifunctional contrast agentsPolymer scienceDual mode
The invention provides a polyphenol-based coordination polymer nano-particle which is prepared from polyphenol, ferric iron salt and polyethylene glycol-modified polyglutamic acid. The polyphenol, the ferric iron salt and the polyethylene glycol-modified polyglutamic acid are adopted and coordinated to prepare the polymer nano-particle; the polymer nano-particle has the advantages that the preparation is simple, the condition is mild, the operation is easy, the sources of raw materials are low-toxic or non-toxic, and the price is low. The prepared coordination polymer nano-particle has a long circulatory function; the particle size ranges from 80nm to 110nm, the polymer nano-particle has an appropriate nano size, an EPR (electron paramagnetic resonance) effect can be realized, and accumulation can be realized in a tumor area. The polymer nano-particle has a dual mode imaging function, i.e., photoacoustic imaging and magnetic resonance imaging; the polymer nano-particle can be used for performing accurate photothermal therapy under the guidance of imaging.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Isoindole nitrogen oxide free radical modified polyaniline and synthetic method and application thereof
The invention discloses an isoindole nitrogen oxide free radical modified polyaniline and a preparation method and an application thereof. 2-, 3-, 5- and 6-site side groups in aniline repeating structural units of a polyaniline high molecular material are chemically modified by an isoindole nitrogen oxide free radical derivative to obtain the product. Or 2-, 3-, 5- and 6-site side groups of aniline monomers are chemically modified by the isoindole nitrogen oxide free radical derivative, and then a polymerization reaction is carried out to obtain the product. Compared with polyaniline, the free radical polymer has better electrical conductivity, higher charge storage density, better capacitance retention rate, fast electrode reaction dynamics performance, and oxidation-reduction ability and characteristic three-line electron paramagnetic resonance spectra similar to isoindole free radicals; and the polymer has good rate capability and cycle stability in the processes of charging and discharging, and is expected to become a novel high-capacity and high-power battery material.
Owner:WUHAN INSTITUTE OF TECHNOLOGY
Methods and apparatus for post-exposure determination of ionizing radiation dose
ActiveUS7084628B2Quantity maximizationRapid and comfortable positioningChemical dosimetersMeasurements using electron paramagnetic resonanceDosimetry radiationIn vivo
The instant invention provides in-vivo methods and apparatus for radiation dosimetry assessment in individuals exposed to potentially harmful radiation, based on measurements in-situ of the teeth. The in vivo dosimetry assessment methods and apparatus utilize electron paramagnetic resonance (EPR) techniques; and employ an apparatus comprising an integrated EPR spectrometer system, an ergonomic magnet and a constructed resonator structure. In various aspects, the dosimetry assessment apparatus is configured to be easily portable and withstand potentially adverse mechanical effects of transportation and deployment in the field. The apparatus also is configured with a power supply that is compatible with both conventional AC line voltages and / or other sources of power suitable for field conditions; and may be easily operated by minimally trained technicians to quickly generate a readout of estimated radiation exposure dose.
Owner:TRUSTEES OF DARTMOUTH COLLEGE THE
Electronic paramagnetic resonance measurement scheme of personal radiation dose
InactiveCN1417572ASmall sizeHigh detection sensitivityMeasurements using electron paramagnetic resonanceDiagnostic recording/measuringWave bandESR - Electron spin resonance
The present invention relates to one kind of electronic paramagnetic resonance measurement scheme of personal radiation dose. It adopts horizontal working magnetic field and x band microwave work frequency, and during detection, magnetic poles of magnet are made to clamp the testee's face across the gum and the upper teech bite into rectangular detection hole in the front end cap of the resonant cavity. This mode ensures the relatively high detection sensitivity. The oral cavity area is held in relatively small magnet and this reaches high homogeneity of magnetic field and high working efficiency of magnetic field. The measurement method is practical.
Owner:RADIOLOGY INST ACAD OF MILITARY MEDICINE SCI PLA
Novel stainless steel submerged-arc welding wire for improving tensile strength after heat treatment
ActiveCN102019517ARaise the percentage contentHigh tensile strengthWelding/cutting media/materialsSoldering mediaThermal treatmentMetal
The invention provides a novel stainless steel submerged-arc welding wire for improving tensile strength after heat treatment, belonging to the technical field of stainless steel welding wires for submerged-arc welding. The stainless steel welding wire provided by the invention comprises the following chemical components in percentage by weight: not more than 0.025 percent of C, not more than 0.60 percent of Si, 1.00-2.50 percent of Mn, not more than 0.02 percent of S, not more than 0.02 percent of P, 19.00-22.00 percent of Cr, 0.00-11.00 percent of Ni, not more than 0.50 percent of Mo, not more than 0.20 percent of Co, 0.07-0.20 percent of N and the balance of Fe. The welding wire benefits the solution to the technical problem that the tensile strength of the deposited metal, generated after tailor-welding heat treatment is carried out on a reactor end socket, is not in accordance to design requirements. The welding wire in the invention is mainly used for the tailor welding of end socket materials of an EPR (Electron Paramagnetic Resonance) nuclear power machine set and the welding of other materials.
Owner:HARBIN WELL WELDING CO LTD
Method for measuring superoxide anion radicals in tape grass leaves
InactiveCN101936930AEasy to operateEasy to masterAnalysis using electron paramagnetic resonanaceSuper oxide dismutasePlant roots
The invention discloses a method for measuring superoxide anion radicals in tape grass leaves, belonging to the measuring field of the measuring of superoxide anion radicals. The method comprises the following steps of: firstly, collecting and cleaning the tip parts of fully exposed small and tender tape grass leaves; carrying out Tiron captureing on the Tiron of radicals in a closed operation box in a closed nitrogen environment; and finally measuring by using an EPR (Electron Paramagnetic Resonance) technology. The invention has the advantages of simpler operation and easy grasping, and can measure the superoxide anion radicals of the tape grass leaves in a very short time;, find that and the measured radicals are found to be the superoxide anion radicals according to the superfine structure constant and, the spectrogram shape analysis of an EPR spectrogram and the combination of the remarkable decreases of the radical strength of the leaves pretreated by SOD (Super Oxide Dismutase), and therefore the invention is the most direct, accurate and effective method for measuring the superoxide anion radicals. Superoxide anions are sensitive to pollutants and have a favorable dosage effect relation. The invention is also suitable for other aquatic plant and terrestrial plant species and can be suitable for measuring the radicals of the plant root tissue.
Owner:NANJING UNIV
Mn4CaO4 core structure-containing water cracking catalyst and preparation method and application thereof
ActiveCN104761591ACatalytic crackingOrganic-compounds/hydrides/coordination-complexes catalystsCatalytic reactionsX-rayElectron spectroscopy
The present invention provides a preparation method and application of a Mn4CaO4 core structure-containing water cracking catalyst, a Mn4CaO4 core structure-containing cluster compound is compounded by cheap metal ions (Mn<2 +> and Ca<2 +> ions), a simple carboxylic ligand and a permanganate, the spatial structure is detected by single crystal X-ray diffraction, and physicochemical properties are characterized by electron spectroscopy, electrochemistry and electron paramagnetic nuclear magnetic resonance technology and the like. The cluster compound can catalyze the water cracking in the presence of an oxidant for release of oxygen, and also can catalyze the water cracking on the electrode surface, and electrons are released to the electrode surface to form a current.
Owner:INST OF CHEM CHINESE ACAD OF SCI
System And Method Using Coupler-Resonators For Electron Paramagnetic Resonance Spectroscopy
InactiveUS20110130647A1Measurements using electron paramagnetic resonanceDiagnostic recording/measuringMultiple sensorSpectroscopy
A coupler-resonator for electron paramagnetic resonance (EPR) spectroscopy in subjects has a wire loop formed into a coupling loop, a central transmission portion, and sensor loops. The sensor loops hold EPR sensor materials and are coated with biocompatible plastic. The coupler-resonator is implanted in a subject, the subject in a nonuniform magnetic field with a pickup coil for RF response measurement apparatus near the subject's skin and inductively coupled to the coupling loop. Resonances are measured at multiple sensor loops distinguished by sweeping magnetic field or radio frequency. A biopsy sampler has an outer needle with sensor loop and a central sampling needle with cavity for biopsy samples and EPR sensor material. A device for EPR of fingernails has sensor loops in a partial glove for holding loops next to fingertips. A device for EPR of teeth has sensor loops in plastic chips that can be held between the teeth.
Owner:THE TRUSTEES OF DARTMOUTH COLLEGE NONEPROFIT CORP
Automatic frequency controller
ActiveCN105790730AImprove signal-to-noise ratioHigh sensitivityAutomatic frequency control detailsSignal-to-noise ratio (imaging)Automatic frequency control
The invention provides an automatic frequency controller which comprises a frequency setting module and a frequency correcting module, wherein the frequency setting module is used for setting the frequency of a first wave source signal, and the frequency correcting module is used for correcting the frequency to the chamber resonant frequency. In this way, frequency setting and frequency correction functions are separated from each other. Under frequency separation conditions, the frequency setting module and the frequency correcting module can select sensitivity freely. Since the amplitude of signals generated in a signal generation module is low when the sensitivity of the frequency correcting module is high, the signal-to-noise ratio of the first wave source signal output by the automatic frequency controller is low. The frequency correcting module in the automatic frequency controller can select a device with low sensitivity to increase the amplitude of signals generated in the signal generation module. The signal-to-noise ratio of the first wave source signal output by the automatic frequency controller is thus increased. When the signal-to-noise ratio of the first wave source signal output is increased, the signal-to-noise ratio and sensitivity of corresponding electron paramagnetic resonance spectrometer are increased.
Owner:UNIV OF SCI & TECH OF CHINA
Method for directly detecting drainage oil by using paramagnetic resonance wave spectroscopy
InactiveCN102590257AEasy to detectAnalysis using electron paramagnetic resonanaceMagnetic resonance spectroscopicResonance
The invention relates to a drainage oil detecting method. Free radicals in an oil product are detected by using an electronic paramagnetic resonance wave spectrometer, and whether the oil product is drainage oil or whether drainage oil is doped in the oil product is judged by comparing the variation trend of the quantity of free radicals before and after temperature change. The method for in-situ test of a sample is wide in applicability, has a good detection effect on various oil products, and can be used for directly detecting whether the drainage oil is doped in the edible oil products.
Owner:TSINGHUA UNIV
Electron paramagnetic resonance cavity for in-vivo measurement of human teeth
ActiveCN102657559ASimple structureEasy to processDentistryDiagnostic recording/measuringRadiation DosagesElectron
The invention relates to an electron paramagnetic resonance cavity capable of measuring human teeth in vivo. The resonance cavity is in a cylindrical shape, a rectangular detection port is arranged on the lateral face of a cavity body and penetrates along the lateral face of the cylinder in a chordwise mode, and the long side of the rectangular detection port is perpendicular to the direction where microwave magnetic-field components in the resonance cavity are located and is parallel to the direction of a current line located on the cavity wall. A pair of modulating coils is arranged on two sides of the detection point to enable the magnetic field modulation to work in the detection port. An allocation bolt outside a coupling hole is utilized to achieve coupling regulation between the cavity body and a microwave system. The whole structures of the resonance cavity and a coupling unit are made of brass. The electron paramagnetic resonance cavity is mainly used for in-vivo electron paramagnetic resonance (EPR) measurement of human teeth, achieves quick estimation of radiation dosage, and can implement paramagnetic resonance detection on samples which cannot be placed in the resonance cavity conveniently due to large volume or of which integral structures are not suitable for being damaged outside the cavity.
Owner:INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
Isoindole nitrogen oxide free radical modified polypyrrole and preparation method and application thereof
InactiveCN104530426AGuaranteed long-term reversibilityGuaranteed charge and discharge rate performanceCell electrodesCapacitancePolypyrrole
The invention discloses an isoindole nitrogen oxide free radical modified polypyrrole and a preparation method and an application thereof. 3- and 4-site side groups in pyrrole repeating structural units of a polypyrrole high molecular material are chemically modified by an isoindole nitrogen oxide free radical derivative to obtain the product. Or 3- and 4-site side groups of pyrrole monomers are chemically modified by the isoindole nitrogen oxide free radical derivative, and then a polymerization reaction is carried out to obtain the product. Compared with polypyrrole, the modified polypyrrole has better electrical conductivity, higher charge storage density, better capacitance retention rate, fast electrode reaction dynamics performance, and oxidation-reduction ability and characteristic three-line electron paramagnetic resonance spectra similar to isoindole free radicals; the polymer has good rate capability and cycle stability in the processes of charging and discharging; and after 500-cycle charging and discharging circulation, the coulomb efficiency can be still kept at 95% or more, and the modified polypyrrole is expected to become a novel high-capacity and high-power battery material.
Owner:WUHAN INSTITUTE OF TECHNOLOGY
Hyaluronic acid-modified silicon-encapsulated drug-loading phospholipid liquid fluorocarbon nanosphere ultrasonic contrast agent and preparation method thereof
InactiveCN107213476AThe synthesis process is simpleShort timeOrganic active ingredientsEchographic/ultrasound-imaging preparationsSide effectUltrasound contrast media
The invention discloses a hyaluronic acid-modified silicon-encapsulated drug-loading phospholipid liquid fluorocarbon nanosphere ultrasonic contrast agent and a preparation method thereof. The hyaluronic acid modified silicon-encapsulated drug-loading phospholipid liquid fluorocarbon nanosphere ultrasonic contrast agent prepared through an emulsification-silicon precipitation method has the particle size of approximately 274.5nm; the passive targeting can be realized through an EPR (Electron Paramagnetic Resonance) effect of a tumor site. Meanwhile, modifying hyaluronic acid can be also used for realizing the active targeting on a tumor cell; thus, the toxic and side effects of a preparation can be decreased; the curative effect of a drug is enhanced. On the other hand, compared with a phospholipid liquid fluorocarbon nanosphere, a hyaluronic acid modified silicon-encapsulated drug-loading phospholipid liquid fluorocarbon nanosphere prepared by the method has favorable stability and a lasting ultrasonic contrast effect. The hyaluronic acid modified silicon-encapsulated drug-loading phospholipid liquid fluorocarbon nanosphere ultrasonic contrast agent has the advantages of simple and convenient process, good biocompatibility of used materials, no use of a toxic surfactant, and wide application prospect.
Owner:CHONGQING MEDICAL UNIVERSITY
Cylindrical electron paramagnetic resonance probe for detecting external sample
ActiveCN103033526ASimple structureEasy to processDentistryDiagnostic recording/measuringMicrowave cavityResonant cavity
The invention relates to a cylindrical electron paramagnetic resonance probe capable of locally detecting an external sample. The probe is rectangular; a cylindrical microwave cavity is formed inside the probe; a polygon sample detecting hole is formed in the center of the top surface of the probe; the detecting hole penetrates longitudinally to the interior of a microwave cavity body space in the wall thickness direction, and penetrates through in the cavity thickness direction; a long edge of the detecting hole cuts a microwave magnetic field component in a resonant cavity and is parallel to the current line direction of the detecting hole in the cavity wall; a pair of coils for providing a regulated magnetic field is placed on the both sides of the detecting hole, and generates the regulated magnetic field required by paramagnetic resonance at the detecting hole; a coupling is coupled with a tuning unit by a coupling hole; and a coupling constant of the resonant cavity and a microwave system is regulated by an adjusting bolt outside the coupling hole. The probe is mainly used for conducting local EPR (electron paramagnetic resonance) detection on the sample that a whole structure is inconvenient to damage.
Owner:INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
Apigenin-carrying hyaluronic acid targeted nano assembly and preparation method thereof
InactiveCN107096034AGood biocompatibilityGood in vivo degradabilityOrganic active ingredientsPharmaceutical non-active ingredientsApigeninSide effect
The invention discloses an apigenin-carrying hyaluronic acid targeted nano assembly and a preparation method thereof. The system is composed of hydrophilic polysaccharide sodium hyaluronate and a hydrophobic drug namely apigenin. During preparation, firstly, sodium hyaluronate and apigenin powder are fully ground in a grinding bowl; then, the mixed powder is taken to mix with distilled water, and a primary nano suspension is obtained by stirring; and finally, ultrasonic treatment is performed with an ultrasonic cell crusher to obtain the apigenin-carrying hyaluronic acid targeted nano assembly. The drug carrier system disclosed by the invention significantly improves the dissolution rate of a drug and has good physical stability. The other outstanding advantage of the drug carrier system is that the particle size is small, the average particle size is less than 200nm, and passive targeting can be realized by virtue of an EPR (electron paramagnetic resonance) effect of a tumor location. Meanwhile, hyaluronic acid is taken as a carrier, so that the apigenin-carrying hyaluronic acid targeted nano assembly can realize active targeting, reduce toxic and side effects, and improve the treatment efficiency of an antitumor drug.
Owner:CHONGQING MEDICAL UNIVERSITY
Three-level multi-user quantum signaling transmission method based on entanglement swapping
The invention discloses a three-level multi-user quantum signaling transmission method based on entanglement swapping. A primary quantum signaling swapper corresponding to a calling subscriber is provided with an electron paramagnetic resonance (EPR) entanglement source used for generating two entanglement particles (1) and (4), wherein the entanglement particle (4) is sent to the calling subscriber and the entanglement particle (1) is sent to a quantum signaling centrex; a primary quantum signaling swapper corresponding to a called subscriber is also provided with an EPR entanglement source used for generating two entanglement particles (2) and (3); the entanglement particle (3) is sent to the called subscriber and the entanglement particle (2) is sent to the quantum signaling centrex; different particle states of two entanglement particles represent different types of quantum signaling; and in the quantum signaling centrex, quantum signaling swapping between the called subscriber and the calling subscriber is finished through Bell state measurement performed by the entanglement particles (2) and (1).
Owner:XIDIAN UNIV
Method for detecting influence of electron beam irradiation on free radical concentration of coal by virtue of electron paramagnetic resonance
InactiveCN103472083AAids in processingLearn about featuresAnalysis using electron paramagnetic resonanacePhysical chemistryParticle physics
The invention relates to a method for detecting the influence of electron beam irradiation on free radical concentration of coal by virtue of electron paramagnetic resonance. The method comprises the following experiment steps: (1) carrying out pretreatment on a coal sample; (2) irradiating the coal sample by electron beams of different doses; and (3) carrying out ESR (electron spin resonance) analysis on the coal sample before and after electron beam irradiation. By carrying out electron beam irradiation on the coal sample subjected to pretreatment, the coal sample with different irradiation doses can be obtained by controlling an electron accelerator. Then, analysis on Lande g factor, free radical concentration Ng, peak width delta H and peak height Hpp is carried out on the coal sample before and after electron beam irradiation so as to research the change of a coal structure. The method has the advantages that the operation is relatively simple and easy to master, the change of the free radical concentration of the coal can be measured in short time, and a good dose effect relation can be achieved, thereby laying a foundation for further research on a coal macromolecular structure.
Owner:SHANGHAI UNIV
Systems and methods for assessment of oxygenation
InactiveUS20130127466A1Simple designMaximize sensitivityMeasurements using electron paramagnetic resonanceDiagnostic recording/measuringEngineeringElectron
A scanner for assessing localized oxygenation of a desired region of interest includes a handheld housing having a proximal end and a distal end. A resonator coil is disposed within the housing and also disposed adjacent the distal end of the housing. The resonator coil is configured to both excite and read paramagnetic materials. A magnet is disposed within the housing and also disposed adjacent the distal end of the housing. The magnet is configured to provide a substantially uniform magnetic field over the desired region of interest. The scanner is configured to use electron paramagnetic resonance to assess localized oxygenation in the desired region.
Owner:O2 INSIGHTS
Tumor-targeted zinc-based metal-organic framework drug carrier and preparation method thereof
ActiveCN103877577AWide variety of sourcesEasy to getPharmaceutical non-active ingredientsAntineoplastic agentsTumor targetSide effect
The invention relates to a tumor-targeted zinc-based metal-organic framework drug carrier. The drug carrier comprises a zinc-based metal-organic framework and folic acid molecules, wherein the zinc-based metal-organic framework is formed by a solvent thermal reaction between zinc nitrate and a 2-amino-1,4-terephthalic acid and has a molecular formula of Zn4O (C8H5NO4)3, and the folic acid molecules are coupled to the zinc-based metal-organic framework through a modification method after synthesis. The invention also provides a preparation method of the tumor-targeted zinc-based metal-organic framework drug carrier. The drug carrier disclosed by the invention can be prepared from raw materials wide in sources, the preparation method is simple and the drug loading capacity is extremely high. The tumor-targeted zinc-based metal-organic framework drug carrier disclosed by the invention has a dual function of passive targeting of EPR (Electron Paramagnetic Resonance) and active targeting of folic acid so that the drug-carried tumor-targeted zinc-based metal-organic framework is effectively targeted and concentrated in a tumor site, thereby achieving an aim of targeted treatment and remarkably reducing the dosage and toxic and side effects of an anti-tumor drug.
Owner:NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
Method of optimizing photostimulated speed level for needle image plates
InactiveUS20080169432A1Allow optimizationElectrical apparatusElectroluminescent light sourcesFrequency spectrumUltimate tensile strength
In a method of annealing a storage phosphor screen comprising a photostimulable phosphor by adding energy in form of heat and / or radiation, said method is applied during a time and in relative humidity conditions such that said phosphor shows peaks in an electron paramagnetic resonance (EPR) spectrum measured at a frequency of 34 GHz, at flux densities of magnetic fields of 880 mT, 1380 mT and 1420 mT, wherein said peaks exceed normalized signal intensity percentages of at least 45% and even of at least 55%, wherein a central peak height in the said EPR-spectrum, measured at a magnetic flux density of 1220 mT, is calculated to have a normalized value of 100%.
Owner:T2PHARMA GMBH
Microwave synthetic experiment instrument
A comprehensive microwave experiment device is provided, which comprises a microwave oscillator, an isolator, a crystal wave detector, an oscillograph, a microwave cymometer, a resonant cavity, a electromagnet and a shorting piston linked in sequence. The device is characterized in that: the resonant cavity and the shorting piston can be replaced by the standing wave measuring line, total reflection copperplate and multi-aperture copper reflector, and student experiments of three modern physics projects on electron paramagnetic resonance, light velocity measurement and the research on microwave characteristics can be carried out.
Owner:王俊华
Rectangular electron paramagnetic resonance (EPR) probe for exo-cavity sample detection
ActiveCN103018269ASimple structureEasy to processAnalysis using electron paramagnetic resonanaceMicrowaveResonance
Owner:INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
Nanoparticulate probe for in vivo monitoring of tissue oxygenation
Owner:THE OHIO STATE UNIV RES FOUND
In-situ measurement method based on electron paramagnetic resonance-magnetic resonance imaging three-dimensional magnetic field
ActiveCN111060853AImprove bias stabilityHigh sensitivityStray field compensationGyroscopeNMR - Nuclear magnetic resonance
The invention discloses an in-situ measurement method based on an electron paramagnetic resonance-magnetic resonance imaging three-dimensional magnetic field. The in-situ measurement method comprisesthe following steps: step 1, performing heating; step 2, performing polarization; step 3, performing electron paramagnetic resonance and magnetic resonance imaging; and step 4, performing three-dimensional magnetic field in-situ measurement. The method has the following beneficial effects: the measurement sensitivity and precision of the residual magnetic field measurement after passive magnetic shielding in the magnetic resonance imaging gyroscope are improved; a sensitive source of the measured magnetic field and a sensitive source for measuring angular motion are located in the same atomicair chamber and are real magnetic fields with nuclear spin feeling, the active magnetic compensation precision is improved and thus the zero-bias stability of the gyroscope is further improved; meanwhile, an atom magnetometer constructed based on the method can work in a geomagnetic field environment, high sensitivity and precision are realized, and the in-situ measurement method can be applied tothe fields of magnetic anomaly detection, geomagnetic navigation, deep space detection and the like.
Owner:BEIJING AUTOMATION CONTROL EQUIP INST
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