The invention discloses a high-yield slow-release selenium-rich and calcium-rich mixed fertilizer. The high-yield slow-release selenium-rich and calcium-rich mixed fertilizer comprises, by weight, 28-40 parts of inorganic nitrogen fertilizers, 35-50 parts of organic nitrogen fertilizers, 5-8 parts of phosphorus pentoxide, 3-5 parts of potassium oxide, 0.1-2 parts of Na2B4O7 10H2O, 0.5-1 part of 2-chlorine-6-nitrapyrin, 0.5-1 part of trace elements, 30-40 parts of eggshell powder, 20-30 parts of corn cobs, 20-30 parts of rice bran and wheat bran, 1-3 parts of gypsum powder, 1-2 parts of shell fossil, 20-25 parts of ginkgo leaf powder, 30-40 parts of fish meal, 10-20 parts of bean pulp, 10-20 parts of straw, 1-2 parts of ionized calcium solvents, 0.5-0.8 part of nano-selenium powder and 10-150 parts of water. The high-yield slow-release selenium-rich and calcium-rich mixed fertilizer has the advantages that different types of calcium are mixed with one another, selenium is added into the calcium, the organic nitrogen fertilizers and the inorganic nitrogen fertilizers are mixed with one another, and the high-yield slow-release selenium-rich and calcium-rich mixed fertilizer is reasonable in proportion and beneficial to excellent growth of crops; the high-yield slow-release selenium-rich and calcium-rich mixed fertilizer can be applied to seeds, accordingly, the seeds are easy to germinate, can sprout neatly and are high in survival rate, and calcium and selenium in the crops can be increased by 1.5-1.8 times.