The invention discloses a zinc-induced-crack-resistant steel plate and a manufacturing method thereof. Low alloy steel subjected to low C-ultralow Si-high Mn-low Als-(Ti+Nb) micro alloying treatment is taken as a basis, the Als content of the steel is appropriately reduced, situations that Mn/C is greater than or equal to 15, [(%Mn)+0.75 (%Mo)]* (%C) is less than or equal to 0.16, Nb/Ti is greater than or equal to 1.8, Ti/N is 1.50-3.40, CEZ is less than or equal to 0.44%, the B content is less than or equal to 2 ppm, and Ni/Cu is greater than or equal to 1.50 are controlled, the Ca treatment is performed, the Ca/S ratio is controlled to be 1.0-3.0, (%Ca)*(%S)0.28 is controlled to be less than or equal to 1.0*10<-3>, and a TMCP (Thermal Mechanical Control Process) is optimized, so that the micro-structure of a finished steel plate is a ferrite-dispersedly distributed tiny bainitic colony, the average grain size is less than 10 mu m, and homogeneous excellent mechanical properties, excellent weldability and zinc-induced-crack-resistant properties are obtained, therefore, the zinc-induced-crack-resistant steel plate is especially suitable for being used as a zinc-spray coating anti-corrosion steel plate for marine structures, a zinc-spray anti-corrosion steel plate for extra-high voltage power transmission structures, a zinc-spray coating anti-corrosion steel plate for coast bridge structures, and the like.