The invention discloses a device and method for detecting acceleration on the basis of back scattered light of nano particle detection. The device comprises a reflective mirror, a light reducing plate, a beam splitter, a light filer, a first focusing lens, first nano particles, second nano particles, grinding taper optical fibers, a rigid connecting rod, a second focusing lens, pinholes, a separating light detector, a laser, a collimating lens, a light intensity modulator, a DSP processor and a micro circulation channel. The device and method for detecting the acceleration on the basis of the back scattered light of the nano particle detection are based on highly sensitive nanoscale displacement measurement, the structure can obtain extremely high measurement resolution of the acceleration and is only restricted by the absolute value of restoring force of light pressure, and meanwhile, a loop-locked control circuit can extend a dynamic measurement range greatly. According to the device and method for detecting the acceleration on the basis of the back scattered light of the nano particle detection, the acceleration of nanoscale displacement is measured without physical contact, the device is not sensitive to other kinds of acting force not in the acceleration direction, and the device and method for detecting the acceleration on the basis of the back scattered light of the nano particle detection have the advantages of being low in noise, high in sensitivity and capable of carrying out high precision identification and analysis, and having feedback functions.