The invention discloses a medicine for alleviating postoperative chemotherapy-induced nausea and vomiting of a patient with an encephaloma and a preparation method. The medicine comprises the following raw materials: hyacinth bletilla, rhizoma zingiberis, cortex magnoliae officinalis, oxhide gelatin, liquorice, pig tripe, pig skin, semen strychni, valeriana officinalis, hindu datura flowers, eucommia, wild ginger, globose phaenosperma herb, silverweed cinquefoil roots, rabdosia amethystoides, radix morindae officinalis, rhizoma atractylodis, auriculate swallowwort roots, elecampane, katsumade galangal seeds, hindu lotus leaf-base, desmodium, fiveleaf akebia fruits, princesplume ladysthumb fruits, chirita fimbrisepala, ghostplant wormwood herb, false Chinese swertia herb, rust-coloured crotalaria herb with roots, ficus esquiroliana, astragalus smicus, fewflower wildrice fruits and ganoderma lucidum. The medicine has the beneficial effects that the medicine takes treatment principles of regulating a spleen, harmonizing a stomach, stopping vomiting, strengthening the spleen, replenishing qi, excreting dampness, protecting gastric mucosa and enhancing the immunity; a preparation process is simple; the curative effect is definite; the toxic and side effects are little; the dosing is convenient; the medicine is easy to prepare and low in cost; the possibility of relapse after treatment is low; the medicine property is specific; and the medicine can treat a specific disease rapidly and effectively.