108 results about "Superoxide dismutase activity" patented technology

The invention relates to a composite hydrogel dressing for promoting wound healing as well as preparation and application thereof, and belongs to the technical field of biological medicines. The hydrogel disclosed by the invention is prepared by mixing gelatin, oxidized dextran and metal ion modified metal-organic framework compounds (MOF-Ag and MOF-Cu). In the mixed solution, amino groups in the gelatin and aldehyde groups of the oxidized dextran are subjected to a Schiff base cross-linking reaction, and the composite hydrogel is formed after standing. The loaded MOF-Ag has antibacterial and anti-biofilm effects on staphylococcus aureus and escherichia coli, and the loaded MOF-Cu has similar superoxide dismutase activity and similar glutathione peroxidase activity, so that excessive active oxygen can be removed, and inflammatory response can be relieved. The obtained hydrogel has good biocompatibility, proper mechanical properties and biological adhesion, stable rheological properties, excellent antibacterial and anti-inflammatory functions and a certain hemostatic function.

The invention discloses a continuous cropping Chinese cabbage planting method based on a microbial agent and application, and belongs to the technical field of crop cultivation. According to the planting method, Chinese cabbage and garlic are intercropped according to the ratio of 1: 1, and a trichoderma harzianum agent is applied. Results show that the planting method can significantly increase the growth indexes such as the plant height, the root length, the leaf chlorophyll content and the soluble sugar content of the Chinese cabbage; the soluble protein content, the peroxidase activity, the superoxide dismutase activity and the malondialdehyde content of the Chinese cabbage leaves are obviously reduced. Meanwhile, the content of rapidly available phosphorus, rapidly available potassium, effective calcium and other substances in the soil can be increased; the activities of urease, catalase and alkaline phosphatase in the soil are also obviously improved. In addition, the number of fungi, bacteria and actinomycetes in the soil is also remarkably increased. Therefore, according to the planting method, the quality of continuous cropping soil can be improved, Chinese cabbage growth is promoted, and theoretical support is provided for healthy and sustainable development of the Chinese cabbage industry.

The invention discloses a brassica rapa alkali extract with anti-hypoxia activity as well as a preparation method and application of the brassica rapa alkali extract. The method comprises the following steps: by taking brassica rapa tuberous roots as a raw material, rinsing, slicing, drying, crushing, extracting with a food-grade calcium oxide alkaline solution, carrying out centrifugal separation to obtain supernate, and carrying out spray drying on the supernate to obtain the brassica rapa alkali extract. The method is easy to operate, low in cost and high in extraction rate, starch and crude fiber auxiliary components in the brassica rapa tubers can be removed to a large extent, the most important components with health-care functions of brassica rapa are reserved, and the biological activity of nutritional components of brassica rapa is kept. Results of evaluation and biochemical index determination of a normal-pressure closed experiment and a sodium nitrite poisoning experiment show that the brassica rapa alkali extract can remarkably prolong the survival time of mice, improve the activity of superoxide dismutase in the mice and reduce the content of malondialdehyde, and shows a relatively good hypoxia tolerance effect. The alkali extract can be used for developing hypoxia-resistant functional foods such as tabletted candies and biscuits, and has a wide application prospect.

The invention discloses a method for evaluating and screening salt tolerance of triticale germplasm resources in a germination stage, and belongs to the technical field of evaluation and screening of plant salt tolerance, salt stress concentration screening: triticale seeds are treated by NaCl solutions with different concentrations, indexes such as survival rate, plant height and overground part fresh weight are measured, the NaCl solution with the concentration of 200 mmol. L <-1 > is determined as the salt tolerance evaluation appropriate concentration, and the salt stress concentration is determined as the salt tolerance evaluation appropriate concentration. Salt tolerance evaluation test: carrying out salt stress treatment by adopting a 200mmol. L <-1 > NaCl solution, determining phenotypic indexes such as survival rate, plant height, fresh weight of overground part, root length and chlorophyll content, and physiological and biochemical indexes such as catalase, peroxidase and superoxide dismutase activity and malondialdehyde content, and carrying out principal component analysis, membership function analysis and clustering analysis to obtain a salt tolerance evaluation result. Calculating a salt tolerance comprehensive evaluation value, and screening salt tolerance triticale germplasm resources.

The invention discloses marasmius albus DCY6478 as well as a culture medium and application thereof, and belongs to the technical field of microorganisms. The invention discloses a Marasmilla sp. DCY6478 strain, and the preservation number of the Marasmilla sp. DCY6478 strain is GDMCC (China General Microbiological Culture Collection Center) No.65883. The Marasmilla sp. Experimental verification results show that the culture medium formula most suitable for growth of the white marasmius is prepared from the following components in percentage by weight: 40% of apple sawdust, 36% of corncob, 14% of cottonseed hull, 1% of lime and 1% of gypsum; the fermentation liquor is verified to have an inhibition effect on a plurality of pathogenic bacteria; the DPPH free radical scavenging capacity of the fermented hyphae is verified, the superoxide dismutase activity and catalase activity are both higher than those of sporocarp, and the fermented hyphae can be used as a natural antioxidant source; it is verified that fermented hyphae or sporocarp of the strain have the capacity of secreting amino acid and polysaccharide and producing crude protein, and a new raw material selection is provided for the industries of food, medicine and the like.

The invention belongs to the technical field of aquaculture, and particularly relates to application of resveratrol in culture of penaeus vannamei boone, which is characterized in that the application dosage and mode of the resveratrol are that the penaeus vannamei boone is fed according to the weight proportion of 0.033-0.067 per thousand of the total weight of the penaeus vannamei boone everyday. The resveratrol is used for improving the immune function of penaeus vannamei boone, improving the survival rate, increasing the body weight growth rate and counting immune cells. The resveratrol is also used for improving the anti-oxidative stress capability of the South America white, including improving the superoxide dismutase activity of the shrimp body, and / or improving the shrimp hepatopancreas lysozyme activity of the shrimp body, and / or improving the total anti-oxidative capability of the shrimp body. The resveratrol can enhance the immune epidemic prevention level of the penaeus vannamei population on stress sources such as vibrio infection, reduce the oxidative stress risk of the penaeus vannamei population and avoid the expansion of breeding loss caused by group stress.

The present invention discloses a preparation method of CFS nanozyme. This nanozyme has broad-spectrum bactericidal property, has low toxicity to normal cells, and there is no problem of bacterial drug resistance, and is expected to be used in the field of antibiotic-free sterilization. The CFS-ion-MN wound repair microneedle patch provided by the present invention, as a wound dressing, can transdermally deliver the antibacterial CFS nanozyme to the deep part of the wound, effectively kill bacteria. The CFS nanozyme can also inhibit inflammation in the body through its superoxide dismutase-like activity, promote wound healing, and promote the antibacterial and healing of the wounds of mice infected with Staphylococcus aureus. Among them, Co 2+ and Fe 3+ can inhibit the IL-17 and NF-κB signaling pathways, thereby accelerating wound closure.

The invention belongs to the technical field of preparation of nano functional materials, and provides a difunctional nanosheet as well as a preparation method and application thereof. On the basis of two-dimensional layered double-metal oxides (LDHs), magnesium-aluminum hydrotalcite (MgAl-LDH) is prepared as a main body laminate, and bioactive components Ce < 3 + > and Sr < 2 + > are introduced into the main body laminate, so that the bifunctional nanosheet capable of accurately and efficiently removing ROS and promoting angiogenesis is developed; wherein due to the existence of Ce < 3 + > and Sr < 2 + >, the nano-sheet has the activity of superoxide dismutase and the characteristic of promoting vascular regeneration at the same time, active sites fully exposed on the surface of the nano-sheet can effectively remove ROS and regulate an anoxic microenvironment, meanwhile, the nano-sheet responds to an ischemic acid microenvironment to release Sr < 2 + >, proliferation and migration of endothelial cells are promoted, and angiogenesis is facilitated. The MgSrCeAl-LDH nanosheet disclosed by the invention is used for treating the MIRI, and the treatment effect is remarkable.

The invention discloses application of polydatin in preparation of a medicine for relieving hepatotoxicity caused by zearalenone, and belongs to the technical field of biological medicine. The invention reveals that polydatin inhibits hepatotoxicity caused by zearalenone through targeted xanthine oxidase for the first time, so that the toxicity of zearalenone to an organism is relieved. Polydatin can be directly combined with xanthine oxidase to inhibit the catalytic activity of xanthine oxidase, so that the oxidative stress injury of the liver after ZEA exposure is reduced, meanwhile, the content of malondialdehyde (MDA) in the liver can be remarkably reduced, the activity of superoxide dismutase (SOD) is improved, the liver oxidation-antioxidant balance is recovered, and liver cells are protected from oxidative injury of ZEA. The invention provides a new scientific basis and development direction for application of polydatin in the fields of mycotoxin detoxification, oxidation resistance, liver protection and the like.

Complexes of polyoxometalate (POM) cluster anions and metal oxide nanocrystal (NC) cores (POM-NC) with tunable NC surface protonation are disclosed. These protonated POM-NC complexes enable precise control over catalytic properties, enhancing catalytic activity under near-neutral pH conditions while improving stability and solubility across various applications. The protonated POM- metal oxide complexes facilitate the activation of airborne O2 under ambient conditions and the production of reactive oxygen species (ROS), including hydroxyl radicals, superoxide, and peroxides. In certain catalytic processes, these complexes mimic enzymatic functions, such as oxidase, peroxidase, catalase, and superoxide dismutase activity, making them valuable for various biological, therapeutic, chemical and environmental applications such as applications related to oxidative catalysis and ROS scavenging.

The invention is suitable for the technical field of pesticide residue detection, and provides a method for distinguishing and detecting pesticide based on copper-platinum bimetallic nano-enzyme. According to the method, a colorimetric sensing array with three sensing channels is constructed by synthesizing a copper-platinum bimetallic nano-enzyme (CuPtNPs) with oxidase-like activity, laccase-like activity and superoxide dismutase-like activity. A fingerprint spectrum is obtained based on specific effects of different pesticides and enzyme-like activities, and qualitative distinguishing and quantitative detection of various pesticides are realized by combining a machine algorithm. According to the method, nine pesticide residues can be measured at a time, six of the nine pesticide residues can be quantitatively analyzed, and the problem that a traditional method only can be used for single detection is solved. A strategy of constructing three channels based on a single nano-enzyme receptor CuPtNPs has the remarkable advantages of simple synthesis process, convenient operation flow and low detection cost, is good in applicability in actual agricultural product samples such as Chinese cabbages and apples, and provides an efficient solution for high-throughput detection of pesticide residues.

The invention discloses preparation of an antibacterial copper-based nano-enzyme fiber dressing capable of promoting wound healing, and belongs to the technical field of medical use. According to the method, 5, 6-dimethylbenzimidazole and copper salt are used as raw materials, the copper-based nano-enzyme is synthesized through a hot bath reaction method of a solvent, reactants are uniformly dispersed in a solution, and the defects that traditional nano-enzyme element components are not uniform, and active sites are low in density are overcome. The prepared copper-based nano enzyme has a unique metal active center, and has oxidase-like activity, catalase-like activity and superoxide dismutase-like activity. According to the copper-based nano-enzyme Cu-NPs II, the activity of oxidase can be achieved without hydrogen peroxide, active oxygen can be generated to achieve the bactericidal effect, when excessive ROS is generated, superoxide dismutase-like activity of the copper-based nano-enzyme Cu-NPs II converts the excessive ROS into H2O2, and due to the fact that the copper-based nano-enzyme Cu-NPs II has catalase-like activity and can decompose H2O2 into water and oxygen, the copper-based nano-enzyme Cu-NPs II has good microenvironment adjusting capacity.

The invention belongs to the technical field of crop cultivation, and particularly relates to application of gamma-aminobutyric acid in relieving saline-alkali stress of cotton and a method for relieving the saline-alkali stress of the cotton. According to the method, gamma-aminobutyric acid is used as an exogenous additive, and when the cotton is stressed by a secondary salt solution with the salt content of 0.45%-0.47% and the pH value of 7.5-8.0, the gamma-aminobutyric acid is added into the secondary salt solution; gamma-aminobutyric acid relieves secondary salt solution stress by improving superoxide dismutase activity of cotton, improving peroxidase activity of cotton, reducing malondialdehyde content of cotton, improving catalase activity of cotton, reducing superoxide anion content, reducing H2O2 content of cotton and improving soluble protein content of cotton; compared with other plant growth regulators, the gamma-aminobutyric acid has higher cotton saline-alkali stress relieving activity. And the gamma-aminobutyric acid is an amino acid naturally existing in an organism, has no toxicity to a human body, has no residual toxicity and residual effect after being used for treating cotton, and has practical utilization value.

The invention discloses a schizophyllum commune anti-aging composition capable of regulating cell rhythm and promoting cell autophagy and a preparation method and application of the schizophyllum commune anti-aging composition capable of regulating cell rhythm and promoting cell autophagy, and the schizophyllum commune anti-aging composition capable of regulating cell rhythm and promoting cell autophagy comprises, by weight, 100 parts of schizophyllum commune anti-aging composition capable of regulating cell rhythm and promoting cell autophagy. The composition is prepared from the following components in parts by variety: 0.2 to 2 parts of glutamine amino ethyl imidazole, 0.5 to 20 parts of wheat germ extract and 82 to 95.8 parts of schizophyllum commune fermentation liquor. According to the application, glutamine amino ethyl imidazole and active ingredients in wheat germ and schizophyllum commune fermentation liquor can be effectively compounded; the content of active ingredients such as total sugar and polypeptide in the prepared composition is high. When the product is used, the activity of lysosome and mitochondria in cells can be remarkably improved, the activity of superoxide dismutase is very excellent, and meanwhile, the cell rhythm can be regulated and cell autophagy can be promoted, so that the product prepared by the invention has ideal effects of resisting oxidation, resisting aging, regulating the cell rhythm and promoting cell autophagy; the requirements of modern skin external preparations are met.

The invention relates to the technical field of nano-materials, and discloses a heterogeneous diatomic nano-enzyme as well as a preparation method and application thereof. The invention provides a space confinement regulation and control strategy which is used for constructing a heterodiatomic catalytic center on a nitrogen-doped carbon skeleton and preparing nano-enzyme with structural stability and synergistic catalytic performance. According to the method, a confinement framework formed by self-assembly of first metal ions such as cobalt ions and second metal ions such as zinc ions and organic ligands is used as a template, third metal ions such as iron ions are introduced, and then carbonization heat treatment is performed in a protective gas atmosphere, so that bimetal sites with stable bridging configuration are formed in situ. The obtained nano-enzyme has the catalytic activity of various antioxidant enzymes, including catalase and remarkable superoxide dismutase activity, and has more excellent free radical scavenging capacity compared with a single-metal or non-bridging system.

The invention belongs to the technical field of microbial agents, and particularly relates to a composite microbial agent, a composite liquid microbial agent and application. The invention provides a complex microbial inoculant, which is prepared from bacillus mojavensis W1, bacillus halotolerans L21 and bacillus subtilis M4, wherein the complex microbial inoculant is prepared from bacillus mojavensis, bacillus halotolerans L21 and bacillus subtilis M4, and the complex microbial inoculant is prepared from bacillus mojavensis, bacillus halotolerans L21 and bacillus subtilis M4. The bacillus mojavensis W1, the bacillus halotolerant L21 and the bacillus subtilis M4 in the complex microbial inoculant interact with one another, so that the defense mechanism of plants can be activated, the activity of superoxide dismutase (SOD), the activity of peroxidase (POD) and the activity of catalase (CAT) can be improved, and the content of malondialdehyde (MDA) can be reduced, thereby improving the prevention and treatment effect on the root rot of the cornutgionium axentgii.

Provided is a test method with which mild cognitive impairment (MCI) is detectable and a measurement reagent for use in the test method. A test method for MCI according to the present invention includes a step of measuring the activity of superoxide dismutase (SOD) in a biological sample of a subject.

The application provides application of ABT199 in preparation of a drug for treating muscle atrophy. Compared with the prior art, the application provides a new use of ABT199 in treating muscle atrophy. Experimental research proves that ABT199 administration can significantly restore the exercise capacity of a cachexia-induced muscle atrophy mouse, improve the muscle cross-sectional area of the mouse, restore the reduced glutathione content of the mouse, and improve the superoxide dismutase activity, so as to improve the muscle atrophy phenotype of the mouse and muscle atrophy-related biochemical indexes. ABT199 can significantly restore cell muscle atrophy-related gene and protein expression, and improve the cachexia-induced muscle atrophy phenotype by reducing related inflammatory mediators; ABT199 can significantly improve the mitochondrial membrane potential, increase the expression of mitochondrial neogenesis-related genes, and reduce the production of active oxygen.

The invention belongs to the technical field of microbial control, and particularly relates to a salt-tolerant bacillus, a microbial agent, a preparation method, a control method and application. The invention provides a salt-tolerant bacillus L21 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.35478. The salt-tolerant bacillus L21 can activate the defense mechanism of plants, improve the activity of defensive enzymes in the plants, and enable the plants to have higher oxidation resistance when encountering pathogenic bacteria, so that ROS accumulation is more effectively reduced, MDA is reduced, and the morbidity of root rot is reduced. The result of the embodiment shows that the bacillus halotolerant L21 can improve the activity of superoxide dismutase (SOD), the activity of peroxidase (POD) and the activity of catalase (CAT), reduce the content of malondialdehyde (MDA) and reduce the morbidity of root rot of cornutgionium axataenense.

The invention discloses application of ellagic acid in preparation of a medicine for preventing or treating ionizing radiation injury, and belongs to the technical field of biological medicine and radiation protection. Experiments prove that ellagic acid with an effective concentration can inhibit lipid peroxidation, enhance the activity of glutathione transferase and superoxide dismutase and promote the expression of antioxidant related genes such as sod-1, sod-2, gst-1 and gst-29 and immune related genes such as lys-1, irg-1, irg-2 and mul-1, so that the ellagic acid with an effective concentration can inhibit lipid peroxidation and improve the activity of glutathione transferase and superoxide dismutase. Therefore, oxidative damage, inflammatory response, reduced stress tolerance, accelerated aging and shortened service life caused by ionizing radiation exposure are relieved, and the compound can be applied to preparation of drugs for preventing or treating ionizing radiation damage and is suitable for nuclear accident emergency protection, space radiation protection of astronauts and adjuvant therapy of tumor radiotherapy patients. The invention provides a theoretical basis for developing an efficient and low-toxicity ionizing radiation protective agent based on ellagic acid, and has a wide application prospect.

The invention belongs to the technical field of microbial prevention and control, and particularly relates to bacillus subtilis, a microbial agent, a preparation method, a prevention and control method and application. The invention provides a strain of bacillus subtilis M4, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.35477. The bacillus subtilis M4 is used for preventing and treating root rot of cornutgionium axe. The bacillus subtilis M4 can improve the activity of disease-resistant defensin superoxide dismutase (SOD), the activity of peroxidase (POD) and the activity of catalase (CAT), reduce the content of malondialdehyde (MDA), finally reduce the morbidity and the morbidity index of plant root rot and promote plant growth.

The invention relates to a compound plant extract soothing and repairing composition and a preparation method thereof, and belongs to the technical field of cosmetics. The glacier deuterium-depleted water and superoxide dismutase are mixed to obtain a component A, the activity of the superoxide dismutase can be improved by means of the strong dissolving power and permeability of the deuterium-depleted water, meanwhile, a compound extract prepared by mixing a stephania tetrandra extract, a radix gentianae extract and a pepper kava extract is a component C, and after the component C is mixed with the component A, the superoxide dismutase activity can be improved. In the component A, deuterium-depleted water can well bear active ingredients in the plant extract, in the component B, madecassoside and the humectant are mixed, the moisturizing effect can be fully achieved, and the composition obtained after the component A, the component B and the component C are mixed has the excellent relieving and repairing effect.

The invention discloses a preparation method of a CFS nano-enzyme, and the nano-enzyme has broad-spectrum bactericidal activity, has low toxicity to normal cells, does not have the problem of bacterial drug resistance, and is expected to be used in the field of antibiotic-free sterilization. The CFS-ion-MN wound repair microneedle patch provided by the invention is used as a wound dressing, the antibacterial CFS nano-enzyme can be transdermally delivered to the deep part of a wound to effectively kill bacteria, and the CFS nano-enzyme can inhibit in-vivo inflammation through the activity of superoxide-like dismutase and promote wound healing; the antibacterial and healing of the wound of a mouse infected with staphylococcus aureus is promoted, and the Co < 2 + > and Fe < 3 + > can inhibit IL-17 and NF-kB signal channels, so that the wound closure is accelerated.

The invention belongs to the technical field of protein engineering, particularly relates to a protein tag with superoxide dismutase activity and application, and provides a protein tag which comprises polypeptide or protein with superoxide dismutase activity. On the second aspect, a fusion protein is provided and comprises the protein tag described in the first aspect and at least one target polypeptide or protein, the target polypeptide or protein is not superoxide dismutase, and the target polypeptide or protein is not superoxide dismutase only by using the protein tag disclosed by the invention. According to the present invention, the technical effects of target polypeptide or protein expression quantity detection (SOD enzyme activity detection), target polypeptide or protein protection from oxidative damage, target polypeptide or protein stability improvement and target polypeptide or protein solubility improvement can be simultaneously achieved without adding any additional step compared with the fusion protein expression operation in the prior art; the operation is convenient.

The application discloses a kind of functional adaptability MOF derived zinc-based hybrid material and preparation method thereof, specifically related to orthopedic implant device related material technical field.The zinc-based hybrid material includes zinc element, terephthalic acid organic ligand framework and phosphate radical, phosphate radical is introduced into framework by hydrothermal reaction of zinc-based MOF precursor and sodium phosphate to obtain.The mass ratio of zinc source and terephthalic acid is controlled to (1-3):1 in preparation, the mass ratio of triethylamine and terephthalic acid is (2-4):1, organic solvent is N,N-dimethylformamide, the stirring reaction time of zinc-based MOF precursor is 2-4h, the mass ratio of precursor and sodium phosphate is (0.01-10):1, the volume fraction of ethanol in ethanol aqueous solution is 0-70%, after heating at 160-180 DEG C, temperature is reduced to 130-150 DEG C, and the reaction is preserved for 5-20h.The material has peroxidase-like activity and superoxide dismutase-like activity, has the ability of promoting bone repair while resisting infection, and is suitable as medical implant device surface functional coating.

The invention discloses calf animal coccus PD13 for improving Alzheimer's disease and application of the calf animal coccus PD13, and relates to the technical field of biology. Experiments prove that in an Alzheimer's disease model mouse induced by injecting A beta oligomer into the brain, the Azococcus calvus PD13 can improve spatial learning and memory disorder and autonomous exploration ability of the AD model mouse and relieve damage to neurons in a hippocampal region of the Alzheimer's disease model mouse, so that the effect of protecting the neurons is achieved, and the Azococcus calvus PD13 can be used for preparing a medicine for treating the Alzheimer's disease. According to the present invention, with the application of the animal coccus calves, the content of glutathione in mouse serum and the enzyme activity of superoxide dismutase are increased, and the content of malondialdehyde is reduced, such that the animal coccus calves provides good prevention and treatment effects on the Alzheimer's disease, and the new approach is provided for developing the Alzheimer's disease-related drugs.

The invention discloses indigowoad root derived carbon dots as well as a preparation method and application thereof, and belongs to the technical field of novel biomedical materials. The method comprises the following steps: generating a carbonized product by a one-step hydrothermal method, and separating and purifying to obtain the indigowoad root-derived carbon dots. The carbon dots do not contain metal elements, are non-toxic and high in biological safety, and show good free radical scavenging activity, certain superoxide dismutase-like activity and good biocompatibility no matter in vitro or in vivo. On the basis, the indigowoad root-derived carbon dots also show excellent anti-inflammatory activity, can down-regulate the inflammatory level of cells, relieve the paralysis symptom of AD nematode, relieve LPS-induced memory deterioration of mice and treat LPS-induced mouse Alzheimer's disease, and can be further applied to preparation of drugs for treating neurodegenerative diseases.

The invention discloses preparation and application of a novel ultrasonic-driven nano-enzyme MOF (Hf)-Pt, the novel piezoelectric nano-enzyme MOF (Hf)-Pt is composed of UIO-66-NH2 (Hf) and an ultra-small Pt nano-enzyme and presents a regular octahedron shape, and the diameter of the novel piezoelectric nano-enzyme MOF (Hf)-Pt is 180-200 nm; the piezoelectric effect is achieved, external ultrasonic stimulation is utilized, and variable electrical stimulation is provided through piezoelectric catalysis; in addition, the composite material has the advantages of being small in size and easy to prepare, has catalase-like activity and superoxide dismutase activity at the same time, and has good biocompatibility. The MOF (Hf)-Pt is used as a novel piezoelectric catalyst, and the technical effect of treating OA is achieved by improving the enzyme catalytic activity of the nano-enzyme, relieving oxygen deficit of an inflammation part, recovering the mitochondrial function, removing excessive ROS in an inflammation tissue and promoting cartilage regeneration through the piezoelectric effect.

The present application provides a composition with satiety and weight control and anti-aging, and a preparation method and application thereof. The composition comprises the following raw materials by weight: polysaccharide 11-13 parts, fiber powder 20-25 parts, highland barley powder 12-18 parts, compound powder 18-23 parts, pectin 4-8 parts, ganoderma lucidum powder 6-9 parts, and compound protein 8-12 parts, and relates to the technical field of satiety and weight control and anti-aging compositions. The composition can form an effect of hindering nutrient absorption or prolonging gastric emptying, increase the volume of intestinal contents to achieve satiety, thereby achieving the functions of well controlling weight gain and reducing body weight. In addition, the composition can activate the body's antioxidant enzyme system, improve the activity of superoxide dismutase (SOD), and reduce the content of malondialdehyde (MDA), thereby delaying cell aging and achieving the anti-aging effect.

The invention belongs to the field of medicines, and relates to a scutellarin aglycone derivative as well as a preparation method and application thereof. The scutellarin aglycone derivative has a structure as shown in a formula I. The preparation method comprises the following steps: reacting scutellarin (a compound II) with methanol to obtain a compound III, then reacting with bornyl chloroacetate (a compound IV) to obtain a compound V, and finally carrying out an alkaline hydrolysis reaction to obtain the compound I, the scutellarin aglycone derivative has the effect of preventing or treating cardiovascular and cerebrovascular related diseases, can improve the activity of superoxide dismutase (SOD), inhibit the production of lactic dehydrogenase (LDH) and reduce the malondialdehyde (MDA) level superior to that of scutellarin, has the inhibiting effect on inflammatory factors TNF-alpha, IL-6 and IL-1beta in cell supernatant superior to that of scutellarin, and can be used for preparing a medicine for treating cardiovascular and cerebrovascular related diseases, such as cardiovascular and cerebrovascular related diseases, cardiovascular and cerebrovascular related diseases, cardiovascular and cerebrovascular related diseases, cardiovascular and cerebrovascular related diseases, cardiovascular and cerebrovascular related diseases, cardiovascular and cerebrovascular related diseases and cardiovascular and cerebrovascular related diseases. The invention has the potential of preparing or preventing cardiovascular and cerebrovascular related diseases.