The invention provides a copper-nickel-iron pipeline connection pipe fitting and preparation thereof. The copper-nickel-iron pipeline connection pipe fitting comprises an outwards protruded surface joint, an inwards concave surface joint and a locking nut. The copper-nickel-iron pipeline connection pipe fitting is characterized in that the meshed positions of the outwards protruded surface joint and the inwards concave surface joint are provided with meshed arc surfaces. The preparation includes shove charging, smelting, sampling, analyzing, deoxidizing, refining, casting, forging and pressing, and finish machining. Compared with the prior art, a rubber pad is removed, cost is relatively saved, and the copper-nickel-iron pipeline connection pipe fitting is completely adapted to pipeline connection on the condition of high pressure or high temperature. Meanwhile, as the forging and pressing process is utilized, mechanical performance is improved, non-cutting or little cutting is achieved, alloy material is saved, and production cost is reduced. The copper-nickel-iron pipeline connection pipe fitting has the advantages of being convenient to connect, firm to connect, and high in seal degree, and pipeline connection is safe.