The invention belongs to the radioactive source making technology field and discloses a device used for making a large-area radioactive source. The device mainly comprises a lifting platform vehicle, a leveling table, a plating bath, a plating sheet, a plating liquid protection frame, a power source, a plating pen, a plating pen support and a two-dimensional translation device, wherein the bottom portion of the lifting platform vehicle is provided with rollers, the vehicle body is provided with a rectangular lifting board, the leveling table is arranged above the lifting board, the bottom portion of the leveling table is provided with adjusting pins capable of realizing micro height adjustment, the plating bath is a rectangular one with an opening at the upper portion and is arranged above the leveling table, the dimension of the plating bath is not smaller than the dimension of the plating sheet, the plating sheet is a cathode and is in the plating bath, the plating sheet is connected with a negative electrode of the power source through a cathode connection wire, periphery of the plating sheet is provided with the plating liquid protection frame, the plating pen is taken as an anode, the material of the plating pen is graphite, the plating pen is arranged below the plating pen support, and the plating pen is connected with a positive electrode of the power source through an anode connection wire. The device has advantages of good uniformity, high electro-deposition efficiency, easy operation, relatively low cost and large active region area.