The invention relates to a winding machine with high reliability. The winding machine with high reliability comprises a main body, a bottom plate, a stabilizing mechanism, a dedusting mechanism, a winding, a yarn, a spool, a fixed pipe, a rotating plate, a rotating shaft, a first bearing and a driving device. The stabilizing mechanism comprises a pressure bar, a pressing plate, a first spring, a transmission assembly, a connecting shaft, a fixed bar, two second bearings, two fixing assemblies, two limiting assemblies and two power assemblies. Each power assembly comprises a first lead screw, aball lead screw bearing, a supporting rod and two third bearings. Each fixing assembly comprises a second lead screw and a bushing. The dedusting mechanism comprises a lantern ring, an air extractionassembly, a fixed box, two supporting rods and a plurality of nozzles. The winding machine with high reliability has a function of fixing the spool by means of the stabilizing mechanism, so that thespool does not move up and down during work, and therefore, the probability that the spool and the fixed pipe are separated is reduced and thus, a condition that winding work is affected is prevented.By means of the dedusting mechanism, the winding machine has a function of removing impurities for the yarn, so that the yarn quality is improved.