The invention relates to the technical field of ceramic-metal composite materials, and provides a nickel-based metal oxide ceramic material inertia anode. The nickel-based metal oxide ceramic material inertia anode has a metal phase and a ceramic phase, the metal phase is composed of the principal component Ni and one to two elements of Cu, Co, Zn, Cr, Ag, Fe, Al, V and the like, and an oxide phase is composed of CaO and TiO2; and the inertia anode is prepared through the steps that oxide and metal powder are subject to common ball milling, press molding is carried out, protective atmosphere sintering is carried out, and machining is carried out. The nickel-based metal oxide ceramic material inertia anode has the beneficial effects that electrical conductivity is good, high-temperature oxidation resistance is high, fused salt chemistry corrosion resistance and electrochemistry corrosion resistance are high, the thermal shock resistance is good, and the price is relatively low. The inertia anode is used for an electrolysis process in a chloride fused salt system, can serve as a substitution of a carbon anode, and solves the problems of high consumption and high CO2 emission.