4 results about "Cyanothymidine" patented technology

This invention discloses a pretreatment method for 3-cyanopyridine wastewater, belonging to the field of wastewater pretreatment technology. This method uses a modified magnetic porous adsorbent as its core and achieves continuous pretreatment of 3-cyanopyridine wastewater through a magnetically controlled adsorption separation device. The adsorbent uses a carboxyl-block polyarylene ether nitrile as a stable porous adsorption framework, introducing nitrile-carboxyl dual-target adsorption sites into the molecular chain. Simultaneously, graphene composite magnetic particles are introduced into the carboxyl-block polyarylene ether nitrile, providing rapid magnetic response separation performance. Through the deep synergy of highly selective adsorption and magnetically controlled separation, effective removal and resource recovery of 3-cyanopyridine are achieved. It can maintain stable treatment performance during long-term continuous operation and is suitable for the industrial pretreatment of 3-cyanopyridine production wastewater.

The present invention relates to hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carbonitriles with activity as inhibitors of the deubiquitylating enzyme USP30, having utility in a variety of therapeutic areas, including conditions involving mitochondrial dysfunction, cancer and fibrosis.

The application discloses a 3-cyanopyridine catalytic synthesis process based on a mesoporous molecular sieve, and belongs to the technical field of catalytic synthesis. The process takes 3-methylpyridine, ammonia and oxygen as main raw materials, and continuously synthesizes by relying on a composite mesoporous molecular sieve catalyst. The catalyst constructs a zirconium-cerium co-doped mesoporous silica framework in situ, improves the structural rigidity of the pore channel, and reduces the surface hydrophilicity. Meanwhile, in combination with the reduction and dissolution promotion of hypophosphorous acid and the strong complexation of phosphoric acid, vanadium sources are deeply penetrated into the mesoporous interior, so that the loss and failure of the active catalyst in a high-temperature hydrothermal environment are effectively avoided. Through the precise modification of the catalyst structure and the deep synergy of the continuous reaction conditions, the process realizes extremely high target product selectivity and excellent long-period anti-deactivation performance, and is suitable for large-scale industrialized continuous production of 3-cyanopyridine.

This invention discloses a method for synthesizing 4-bromo-3-cyanopyridine, comprising the following steps: (1) under alkaline conditions, oxidizing the hydroxyl group by phosphorus oxychloride to prepare the intermediate product 2-chloro-3-cyano-4-methoxypyridine; (2) placing the product obtained in step (1) in ethanol, adding palladium on carbon, and slowly introducing hydrogen gas into it to prepare the intermediate product 3-cyano-4-methoxypyridine; (3) adding phosphorus oxychloride to the acetonitrile solution of the product obtained in step (2) to prepare the target product 4-bromo-3-cyanopyridine. The synthesis method adopted in this invention has advantages such as readily available raw materials, mild reaction conditions, recyclable catalyst, no heavy metal pollution, and simple product post-processing, making it suitable for industrial production.