The invention discloses a shedding-prevention and acid-base resistance metal flicker paint for a photo frame. The shedding-prevention and acid-base resistance metal flicker paint is prepared from fluorocarbon resin, polyacrylate emulsion, organic silicon resin, epoxy resin, modified aluminum powder, nano-silica, nanometer titania, ceramic powder, jade powder, stainless steel powder, chrysotile, nitrocellulose liquid, ethylene glycol butyl ether, hexakis methoxymethyl melamine, dimethylethanolamine, isopropanol, sodium hexametaphosphate, butyl acetate, a silane coupling agent KH-570, a dispersing agent TG-755, a flatting agent TG-700, a wetting agent AP-560, a defoaming agent TG-810, xylene and deionized water. The metal flicker paint has excellent acid-base resistance and shedding-prevention performance.