The present invention belongs to the technical field of
organic chemistry, and specifically relates to a method for preparing
rosuvastatin sodium. The method of the invention comprises: reducing 4-p-fluorophenyl-6-
isopropyl-2-(N-methyl-methylsulfonylamino)
pyrimidine-5-
carboxylic acid (VII) in the presence of a
borohydride, an
alkyl-substituted
chlorosilane and an assistance in an
organic solvent to prepare 4-p-fluorophenyl-5-
hydroxymethyl-6-
isopropyl-2-(N-methyl-methylsulfonylamino)
pyrimidine (VIII); then performing a reaction of the compound VIII with a
triphenyl phosphonium salt in an
organic solvent to prepare a ((4-p-fluorophenyl-6-
isopropyl-2-(N-methyl-methylsulfonylamino)-5-pyridyl)-methyl)
triphenyl phosphonium salt (IX); performing a stereoselective Michael
addition reaction of (S)-trans-4,5-dihydroxy-pent-2-olefine acid ester (II) with
furfural (III) to prepare a 2-((4R,6S)-2-(
furan-2-yl)-6-
hydroxymethyl-1,3-dioxane-4-yl)acetate (IV); oxidizing the compound IV to prepare a 2-((4R,6S)-2-(
furan-2-yl)-6-formacyl-1,3-dioxane-4-yl)acetate (V); performing an olefination reaction of the compound V with the (4-p-fluorophenyl-6-isopropyl-2-(N-methyl-methylsulfonylamino)pyrimid-5-yl)-methyl triphenyl substituted
phosphonium salt (IX) or
phosphate to prepare 2-((4R,6S)-6-(trans-2-(4-p-fluorophenyl-6-isopropyl-2-(N-methyl-methylsulfonylamino)pyrimid-5-yl)vinyl)-2-(
furan-2-yl)-1,3-dioxane-4-yl)acetate (VI); and performing deprotection and
sodium salt formation of compound VI to prepare
rosuvastatin sodium (I). The method has easily obtainable raw materials, and is simple to operate and suitable for industrial productions.