The invention discloses a high yield fertilizer capable of enhancing dendrobe quality, and belong to the field of fertilizer. The fertilizer is prepared from a component A, a component B and a component C which are mixed in a ratio of 4:3:1. The component A comprises sorghum straws, rapeseed cakes, pomegranate seeds, tofukasu, soybean meal, corn flour, cow manure, bagasse, distiller grains, soy sauce grains, peanut shells, animal viscus heels and phosphorus slag. The component B comprises urea, ferrous sulfate, magnesium sulfate, cupric sulfate, zinc sulfate, potassium sulfate, sodium molybdate, dihydroxysuccinic acid, boric acid, sodium selenite, prohexadione calcium, ammonium biphosphate, calcium lactate and sodium sulfate. The component C comprises Herba Lagotis, isatis root, flos daturae, Angelica decursiva, rhizoma curcumae longae, Radix Rhapontici seu Radix Echinopsis, herba elsholtziae, Scutellaria baicalensis, Mangnolia officinalis and pasqueflower. The fertilizer can increase the dendrobe yield by 20%. The polyssaccharide content in dendrobe is enhanced by roughly 22%, thus obviously elevating the planting profit, and bearing good promotion and application value.