The present invention discloses a honeysuckle multi-function health preserving wine and a preparation method thereof. The honeysuckle multi-function health preserving wine is characterized by comprising a honeysuckle extract, a ginkgo leaf extract, resveratrol, honey, crystal sugar and an extraction liquid. The honeysuckle multi-function health preserving wine preparation method comprises the following steps: 1, extracting the extraction liquid, 2, extracting the honeysuckle extract, 3, extracting the ginkgo leaf extract, 4, extracting the resveratrol extract, and 5, preparing the honeysuckle multi-function health preserving wine. The invention provides the honeysuckle multi-function health preserving wine and the preparation method thereof, wherein resources such as honeysuckle, ginkgo and giant knotweed rhizome, and nature plants with characteristics of medical use and edible use are completely utilized as the raw materials, and methods such as extraction and refinement are adopted, such that the honeysuckle extract, the ginkgo leaf extract and the giant knotweed rhizome extract are combined with the ingredients so as to well provide medicinal health effects, characteristics of mellow and sweet taste, and fresh and transparent appearance are provided, drinking and health are integrated, and effects of disease prevention and body building are achieved.