The invention belongs to the technical field of gynecology department drugs, and particularly relates to external-use antibacterial powder for gynecology department and a preparation method thereof. The external-use antibacterial powder for gynecology department is mainly prepared by performing raw material treatment, enzymolysis, fermentation, alcohol precipitation, concentration and the like on raw materials such as roots of common peony, Japanese thistle herb, common cephalanoplos herb, fructus cnidii, fructus kochiae, rosin, rhizoma atractylodis, java brucea fruits, radix arnebiae, Radix Saposhnikoviae, sessile stemona roots, yangtao actinidia roots, fructus xanthii, indigo naturalis, radix rhi chinensis, honeysuckle rattans, fine-leaf schizonepeta herb, herba menthae, ephedra herb, glycine bataine, radix rehmanniae glutinosae, figwort roots, clove flower, root-bark of Chinese wolfberry, borneol, diversifolious patrinia roots, cordate telosma flower, dried alum, a color retention agent, a surfactant, compound enzyme and microorganisms. The antibacterial powder has multiple effects of inducing mild diaphoresis and clearing dampness, clearing away heat and toxic materials, enriching the blood and moistening dryness, promoting blood circulation to remove blood stasis, relieving itching and disinfecting, resisting bacteria and inflammatory, relieving pains and stopping bleeding, and the like, has very good relieving effect on gynecological diseases, effectively improves immunity of the human body, is free of side effect and drug resistance; and moreover, a preparation process is simple, and preparation is easy.