The invention provides a dynamic balance cycloidal reduction box provided with an interlayer air-cooling box body and supported by zinc-based alloy bearings. The dynamic balance cycloidal reduction box comprises the box body, an input shaft, a transmission mechanism and an output shaft, and is characterized in that connecting parts of an inner cylinder and a circular end cover are arranged in the box body, the inner cylinder is connected with the box body, the input end of the circular end cover is in close fit with an inner hole of the input end of the box body, the circular end cover is connected with the box body through a circular ring plate, an interlayer is formed by the inner wall of the box body and the outer walls of the connecting parts of the inner cylinder and the circular end cover, an exhaust window is formed in the top of the box body, and a draught fan is arranged on the side portion of the box body; the transmission mechanism comprises four cycloidal gears, pin wheel housings, needle pins and eccentric bearings, the output shaft is arranged in the zinc-based alloy bearings in a supported mode, a T-shaped sponge is arranged in the output shaft, an oil storage cavity Q is formed by the sponge and a shaft hole, lubricating oil flows into a friction surface from a small hole, the alloy bearings are arranged in load balance rings, and an output shaft alloy bearing simply-supported structure is formed. The dynamic balance cycloidal reduction box has the technical advantages that the structure is simple, and cost is low; the air volume is adjusted, so that thermal power approaches to mechanical power; lubrication is reliable, bearing cost is reduced by 60%-80%, steel for the bearings is saved by 50%-70%, and dynamic balance of operation can be achieved.