The invention belongs to the technical field of deep processing for peanut protein, and specifically relates to a method for producing active peptide from peanut cake and meal by immobilized enzyme. The method comprises the steps of: immobilizing two proteases, i.e. alkaline and neutral proteases, by adopting chemically-modified magnetic chitosan micro-particles so as to implement enzymatic hydrolysis, and then centrifuging, decolorizing, desalting by nano-filtration, grading by ultrafiltration and spray-drying to obtain peanut active peptide. Compared with the traditional preparation method,the method has the characteristics of low production cost, short production period, high product yield, high product purity, mild, green and energy-saving production process and the like. In additionto excellent dissolubility, the peanut functional peptide produced by the method provided by the invention has the functions of lowering blood pressure and resisting oxidation, so the active peptide has high market development value.