The invention belongs to the technical field of metal material machining and steel, and particularly relates to a method for preparing an S355MC steel coil based on a multi-mode sheet billet continuous casting and rolling production line and a product obtained from the method for preparing an S355MC steel coil based on a multi-mode sheet billet continuous casting and rolling production line. The method for preparing the S355MC steel coil based on the multi-mode sheet billet continuous casting and rolling production line comprises the following steps that smelting and continuous casting are carried out to obtain a sheet billet, the sheet billet is sequentially subjected to heating treatment, descaling before rough rolling, rough rolling, electromagnetic induction heating, descaling before finish rolling, finish rolling, laminar cooling, coiling and cooling, and an S355MC steel coil is obtained; and the sheet billet comprises the following components of, in percentage by mass, 0.03%-0.15% of C, smaller than or equal to 0.05% of Si, 0.6%-1.5% of Mn, 0.02%-0.35% of Al, smaller than or equal to 0.010% of P, smaller than or equal to 0.005% of S, 0.01%-0.10% of Nb, smaller than or equal to 0.005% of N, and the balance iron and inevitable impurities. The method for preparing the S355MC steel coil expands the thickness range of the final product S355MC steel coil, and has the advantagesof short production line, short process, energy conservation, emission reduction and cost reduction.